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| ID | Type | Description | Link |
|---|---|---|---|
| COG-AALL12B1 | |||
| CDR0000724799 | |||
| AALL12B1 | Other Identifier | COG | |
| NCI-2012-00246 | Registry Identifier | CTRP (Clinical Trial Reporting Program) |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Testing for minimal residual disease in cell samples from patients with acute lymphoblastic leukemia may help doctors plan better treatment.
PURPOSE: This research trial studies a genetic test in identifying previously undetectable minimal residual disease in cell samples from younger patients with acute lymphoblastic leukemia.
OBJECTIVES:
OUTLINE: DNA extracted from diagnostic cells are analyzed for immunoglobulin heavy chain variable region by next-generation sequencing.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cytogenetic analysis | Genetic | |||
| nucleic acid sequencing | Genetic | |||
| diagnostic laboratory biomarker analysis | Other | |||
| laboratory biomarker analysis | Other | |||
| medical chart review | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Identification and characterization of changes in clonal populations of B cells in children with ALL | ||
| Reclassification of patients as MRD positive at day 29 | ||
| Higher sensitivity detection that allow the stratification of the MRD population into 2 groups with lower and higher likelihood of relapse |
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DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Patients With Acute Lymphoblastic Leukemia
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| Name | Affiliation | Role |
|---|---|---|
| Norman J. Lacayo, MD | Stanford University | Principal Investigator |
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cell samples
| ID | Term |
|---|---|
| D007938 | Leukemia |
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| ID | Term |
|---|---|
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007945 | Leukemia, Lymphoid |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D020732 | Cytogenetic Analysis |
| D001483 | Base Sequence |
| ID | Term |
|---|---|
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D005821 | Genetic Techniques |
| D015394 | Molecular Structure |
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D040342 | Genetic Structures |
| D055614 | Genetic Phenomena |
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