The recruiting centre was no longer presenting new patients for inclusion

Quantitative and prognostic evaluation of dense red blood cells in sickle cell children: preliminary single center study from the Creteil pediatric cohort.

An association between red blood cell density and hemolytic parameters, and clinical manifestations has been demonstrated in adults with sickle cell anemia.

This factor has not been studied in children. The identification of predictive biomarkers of disease severity, especially of specific pediatric complications (cerebral vasculopathy, splenic sequestration, Dactylitis) would be useful for optimal care of the children and early intensification Red blood cell density might be one of these prognostic factors.

Inclusion Criteria:

• Age: 18 months-18 years
• Patient with sickle cell disease namely SS, or S / Beta0 or S / Beta +
• Patient regularly followed in the pediatric cohort of the CHI Creteil
• Patient Hospitalized for an annual check-up
• With or without intensification by Hydroxycarbamide
• patient who haven't been transfused within 3 months
• Whose parents have given their informed consent
• Patients insured to the French social scheme

Exclusion Criteria:

• Sickle cell SC disease
• Having received an allogeneic bone marrow transplantation
• Under regular transfusion program
• Having received a transfusion within 3 months

patients with sickle cell disease followed regularly in the CHI creteil hospital aged from 18 months to 18 years old.