Relationship Between Biological Phenotype, Clinical Severity of Sickle Cell Disease, and Blood Coagulation

Relationship Between Biological Phenotype, Clinical Severity of Sickle Cell Disease, and Blood Coagulation

Sickle cell disease is characterized by chronic hemolytic anemia and blood rheological alterations. In addition, blood coagulation abnormalities have been reported in patients with sickle cell disease and hemolysis-derived products could be involved. The investigators hypothesized that patients with sickle cell disease and severe hemolysis (Lactate Dehydrogenase level > 484 IU/L) could have an increased risk of hypercoagulable state and subsequent thromboembolic complications.

Inclusion Criteria:

• Aged 8 years or older
• Under clinical follow-up for a diagnosis of sickle cell disease, specifically genotypes S/S, S/beta0, or S/C
• Patient covered by a social security or equivalent health insurance plan
• Collection of the non-opposition for adults
• Information of the minor and collection of the non-opposition from both parents

Exclusion Criteria:

• Patient who has undergone a transfusion or therapeutic phlebotomy within the 3 months prior to inclusion
• Patient participating in another interventional research protocol that may interfere with the present protocol (at the investigator's discretion)
• Patient under guardianship, curatorship, or legal protection
• Patient subject to a legal protection measure
• Person admitted to a health or social care institution for purposes other than research