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GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of erythropoiesis, red blood cells and iron metabolism, and to develop new therapeutic protocols capable of providing added value in terms of innovation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Affected patients | Biological samples of blood for all patients. Biological samples of saliva, surgical remainder (skin, tumor, kidney,....), saliva, urine, hair. |
| |
| Non affected relatives | Biological samples of blood for all relatives. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biological sampling | Other | Biological samples including blood, surgical remainder, urine,... |
|
| Measure | Description | Time Frame |
|---|---|---|
| Innovative markers of spleen fonctionality | Retention rate (%) of red blood cells using Microsphiltration compared with non affected subjects | 20 years |
| Quantification of inflammation in sickle cell disease | Activation rate of circulating mastocytes (%) | 20 years |
| Markers of post-artesunate hemolysis | Concentration of pitted red blood cells at day 3 | 20 years |
| Correlation between transfusion yield and the storage of red blood cell bags | Increasing in haemoglobin concentration at 6 hours post transfusion | 20 years |
| Efficiency of Phosphodiesterase inhibitor on neutrophil adhesion in Sickle cell disease | Proportional change in adhesion rate (%) of neutrophils measured in the peripheral blood before and after treatment with phosphodiesterase inhibitors | 20 years |
| Quantification of mitochondria removal during erythropoiesis in SDC patients, consequences on the mature RBC | Mitochondria rate and level of ROS in RBC measured by Flow Cytometry | 20 years |
| Study of iron metabolism in Diamond-Blackfan Anemia patients | Dosage of iron metabolism parameters | 20 years |
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Inclusion Criteria:
Exclusion Criteria:
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Inclusion of patients affected by red blood cell disorder and their non affected relatives
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sandra Manceau, PhD | Contact | +33171196435 | sandra.manceau@aphp.fr | |
| Pierre Buffet, MD | Contact | +33142754456 | pabuffet@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Olivier Hermine, MD, PhD | Assistance Publique - Hôpitaux de Paris | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Hôpital de la Mère et de l'enfant Lagune | Not yet recruiting | Cotonou | Benin |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39286963 | Derived | Sissoko A, Cisse A, Duverdier C, Marin M, Dumas L, Manceau S, Maitre B, Eckly A, Fricot-Monsinjon A, Roussel C, Ndour PA, Dussiot M, Dokmak S, Aussilhou B, Dembinski J, Sauvanet A, Paye F, Lesurtel M, Cros J, Wendum D, Tichit M, Hardy D, Capito C, Allali S, Buffet P. Clearance of pathogenic erythrocytes is maintained despite spleen dysfunction in children with sickle cell disease. Am J Hematol. 2024 Dec;99(12):2267-2278. doi: 10.1002/ajh.27481. Epub 2024 Sep 17. | |
| 36730189 |
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Collection of:
| CHU Amiens-Picardie | Recruiting | Amiens | France |
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| Hôpital Privé d'Antony | Recruiting | Antony | France |
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| Hôpital Avicenne | Recruiting | Bobigny | France |
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| Hôpital Pellegrin | Recruiting | Bordeaux | France |
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| Hôpital Beaujon | Recruiting | Clichy | France |
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| Hôpital Louis Mourier | Recruiting | Colombes | France |
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| Hopital Henri Mondor | Recruiting | Créteil | France |
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| CHU Kremlin Bicetre | Recruiting | Le Kremlin-Bicêtre | France |
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| Hopital de la conception | Recruiting | Marseille | France |
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| Hôpital d'Enfants de la TIMONE | Recruiting | Marseille | France |
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| Hôpital Saint Eloi | Recruiting | Montpellier | France |
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| CHU de Niort | Recruiting | Niort | France |
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| Groupe Hospitalier Diaconesses Croix Saint Simon | Recruiting | Paris | France |
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| Hopital Necker - Enfants malades | Recruiting | Paris | France |
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| Hôpital Armand Trousseau | Recruiting | Paris | France |
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| Hôpital Cochin | Recruiting | Paris | France |
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| Hôpital Européen Georges-Pompidou | Recruiting | Paris | France |
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| Hôpital Robert Debré | Not yet recruiting | Paris | France |
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| Hôpital Saint Louis | Recruiting | Paris | France |
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| Hôpital Saint-Antoine | Recruiting | Paris | France |
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| Institut Pasteur | Recruiting | Paris | France |
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| CHU de Rouen | Recruiting | Rouen | France |
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| Hôpital national d'instruction des armées Bégin | Recruiting | Saint-Mandé | France |
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| CHU de la Guadeloupe | Not yet recruiting | Pointe-à-Pitre | Guadeloupe |
|
| Derived |
| Qiang Y, Sissoko A, Liu ZL, Dong T, Zheng F, Kong F, Higgins JM, Karniadakis GE, Buffet PA, Suresh S, Dao M. Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2217607120. doi: 10.1073/pnas.2217607120. Epub 2023 Feb 2. |