The purpose of this study is to evaluate the safety and efficacy of the MIRI-TL time-lapse incubator and CultureCoin dish compared to standard big-box incubators and standard culture dishes used for embryo culture.

Following randomization and standard ovarian stimulation protocols to obtain a sufficient number of mature (MII) oocytes, these oocytes will be fertilized by Intra-Cytoplasmic Sperm Injection (ICSI). If a patient has been randomized to the study group, all inseminated oocytes and subsequently all fertilized diploid (2PN) zygotes will be placed in the CultureCoin and then into the MIRI-TL Time-lapse incubator and cultured as per normal protocol to the blastocyst stage (Day 5/6 or 7). Top quality blastocyst(s) will be transferred and monitored for implantation, pregnancy and ongoing birth. Embryo transfers will either occur in a fresh or frozen embryo transfer cycle.

Inclusion Criteria:

• At least 18 years of age
• Women undergoing in vitro fertilization treatment using their own or frozen oocytes
• Fresh or Frozen Embryo Transfer
• Fertilization by ICSI
• At least 4 diploid (2PN) embryos at fertilization check
• Willing to have all inseminated oocytes imaged by Miri
• Willing to comply with study protocol and procedures Willing to provide written informed consent

Exclusion Criteria:

• Fertilization using surgically removed sperm
• History of cancer

Non-identified data regarding embryo development and pregnancy outcomes may be shared and discussed through presentations and publications.

Project has ceased

Project has ceased

patients in the dishes equal number in incubator

9 months

No adverse events were reported in this study. All-Cause Mortality was not monitored/assessed.