Ocytocine and Cerebral Activation in Relation With Attachement

A Cross Over Randomized Controlled Trial of the Effect of Nasal Ocytocine on Cerebral Activations in Relation With Attachement in the General Population

The study aims to characterize the cerebral activation modifications related to nasal oxytocin administration during vizualisation of distress images in population of healthy people with different attachement styles.

Healthy adult male will be recruited. Their attachement style will be assessed through the Attachement scale interview (ASI).

They will have 2 fMRI sessions, during which emotional images will be presented.

One session will be preceded by a nasal administration of oxytocin and the other session will be preceded by a placebo nasal administration. The order of both administrations will be randomized.

Inclusion Criteria:

• comprehension of french
• having signed the informed consent

Exclusion Criteria:

• chronic disease (liver failure, kidney failure) and cardiovascular disease
• hypertensive treatment
• treatment wich increases QT
• current hospitalisation
• fMRI contraindication
• legal protection