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The study aims to characterize the cerebral activation modifications related to nasal oxytocin administration during vizualisation of distress images in population of healthy people with different attachement styles.
Healthy adult male will be recruited. Their attachement style will be assessed through the Attachement scale interview (ASI).
They will have 2 fMRI sessions, during which emotional images will be presented.
One session will be preceded by a nasal administration of oxytocin and the other session will be preceded by a placebo nasal administration. The order of both administrations will be randomized.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| secure | Experimental | healthy adult male with secure attachement |
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| avoidant | Experimental | healthy adult male with avoidant attachement |
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| enmeshed/fearfull | Experimental | healthy adult male with enmeshed/fearfull attachement |
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| dual style | Experimental | healthy adult male with dual attachement style |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nasal oxytocin or placebo | Drug | nasal administration of oxytocin or palcebo 45 min befor fMRI session |
|
| Measure | Description | Time Frame |
|---|---|---|
| BOLD signal intensity | BOLD signal will be assessed in the brain regions associated with attachement: amygdala, medial prefrontal cortex and dorsolateral prefrontal cortex. Both conditions (placebo vs axytocin) will be compared in the four groups. BOLD signal will be assessed during the visualization of emotional pictures that ellicit distress, comfort or complicity or neural emotion. | 45 min after intranasal administration of oxytocin or placebo |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lauriane VULLIEZ-COADY, MD | Centre Hospitalier Universitaire de Besancon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Besancon | Besançon | Doubs | 25030 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39093338 | Result | Comte A, Szymanska M, Monnin J, Moulin T, Nezelof S, Magnin E, Jardri R, Vulliez-Coady L. Neural correlates of distress and comfort in individuals with avoidant, anxious and secure attachment style: an fMRI study. Attach Hum Dev. 2024 Oct;26(5):423-445. doi: 10.1080/14616734.2024.2384393. Epub 2024 Aug 2. |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| fMRI | Device | FMRI during emotional image visualization |
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| Attachement scale interview (ASI) | Behavioral | this scale is used to determine the attachement style of each participant |
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| psychometric scales | Behavioral | self adminstrated questionnaires which asses the level of anxiety (Spielberger State-trait anxiety interview-STAI), depression (Beck depression inventory-BDI) and alexithymia (Toronta Alexuthymia scale-TAS 20) |
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