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This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay and incidence of chronic pain,et al. single-injection TPVB +continuous(pulsatile infusion) TPVB and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single-injection TPVB +continuous TPVB | Experimental | Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA. |
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| IPCA | Active Comparator | postoperative IPCA is given alone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| single-injection TPVB + continuous TPVB | Procedure | Inject local anesthetics in the T8 paravertebral space followed with catheter insertion and continuous local infusion. |
|
| Measure | Description | Time Frame |
|---|---|---|
| cumulative morphine consumption | within 48 postoperative hours |
| Measure | Description | Time Frame |
|---|---|---|
| The pain scores determined by the numeric rating scale (NRS, 0-10) | At 0, 2,4, 8, 12, 24 ,48,72hours and 7day after the surgery | |
| nausea and vomiting score | At 0, 2,4, 8, 12, 24 and 48hours after the surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yuguang Huang, MD. | Peking Union Medical College Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xulei CUI | Beijing | Beijing Municipality | 100730 | China |
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| Philip CX50 Ultrasound Scanner | Device | The curved (C1-5) probe of Philip CX 50 Ultrasound Scanner is used for scanning |
|
| PAJUNK Contiplex S Catheter | Device |
|
| single dose ropivacaine | Drug |
|
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| continuously infusion of ropivacaine | Drug |
|
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| Morphine given as IPCA | Drug | bolus: 2mg, lock time: 10min, 1h limitation: 8mg |
|
| pruritus score | At 0, 2,4, 8, 12, 24 and 48hours after the surgery |
| ambulation time | within the 7 days after surgery |
| time of recovery of bowl movement | within the 7 days after surgery |
| Postoperative hospital length of stay | Up to 4 weeks |
| patient satisfaction with anesthesia | use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia | 48 hours after surgery |
| data collection of chronic pain | Patients undergo a telephone interview with a questionnaire at 3, 6 and 12 months after surgery, the incidence and severity of chronic pain is recorded. | at 3,6,12 months after surgery |
| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| C052923 | isopropyl cyanoacrylate |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
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