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The purpose of this study is to compare the frequency of hypotension between hyperbaric anesthetics and isobaric anesthetics during cesarean section and determine whether continuous infusion of phenylephrine is effective in mothers who received hyperbaric anesthetics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| "BUPI","P" | Experimental | patients who received hyperbaric bupivacaine and continous infusion of phenylephrine |
|
| "BUPI","N" | Placebo Comparator | patients who received hyperbaric bupivacaine and continous infusion of normal saline |
|
| "LEVO","P" | Experimental | patients who received isobaric levobupivacaine and continous infusion of phenylephrine |
|
| "LEVO","N" | Active Comparator | patients who received isobaric levobupivacaine and continous infusion of normal saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupivacaine | Drug | spinal anesthesia with hyperbaric bupivacaine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of hypotension events with treatment related | blood pressure was obtained every 1min. A 20% decrease or more decrease in SAP compared to baseline was considered as hypotension. Hypotensive events during first 30 min was recorded as primary outcome. | during 30min after spinal anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| total dose of phenylephrine | during the surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bahk | Seoul National University Hospital Seoul, Korea, Republic of | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | Seoul | 110-744 | South Korea |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D000077554 | Levobupivacaine |
| D010656 | Phenylephrine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| Levobupivacaine | Drug | spinal anesthesia with isobaric levobupivacaine |
|
|
| Phenylephrine | Drug | continous infusion of phenylephrine |
|
| normal saline | Drug | continous infusion of normal saline |
|
| D000588 |
| Amines |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |