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The purpose of randomized, double-blind, placebo-controlled study was to determine whether yoghurt drink containing 2g plant stanols (3.4g as plant stanol esters) is effective in the control of blood cholesterol level in subjects with LDL-cholesterol level 130-159mg/dL.
The objective of clinical trial was to evaluate the effect of yoghurt drink containing 2g plant stanols (3.4g as plant stanol esters) on blood cholesterol level. A randomized, double-blinded, placebo-controlled study was conducted on subjects with LDL-cholesterol level 130-159mg/dL. The subjects were randomly assigned to either a group ingesting yoghurt drink containing 2g plant stanols (3.4g as plant stanol esters) or a placebo group (yoghurt drink without plant stanols) for 4-week. The investigators assessed blood cholesterol level.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test group | Experimental | Subjects randomized to the test group consumed yoghurt drink containing 3.4g plant stanol as ester for 1 per day for a period of 4 weeks. |
|
| Placebo group | Placebo Comparator | Subjects randomized to the placebo group consumed yoghurt drink without plant stanol as ester for 1 per day for a period of 4 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Yoghurt drink containing plant stanol as esters | Other |
| ||
| Yoghurt drink without plant stanol as esters |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline LDL-cholesterol at 4-week | at baseline and 4-week follow-up | |
| Change from baseline total cholesterol at 4-week | at baseline and 4-week follow-up | |
| Change from baseline non-HDL-cholesterol at 4-week | at baseline and 4-week follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline triglyceride at 4-week | at baseline and 4-week follow-up | |
| Change from baseline HDL-cholesterol at 4-week | at baseline and 4-week follow-up | |
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Inclusion Criteria:
• LDL-cholesterol level 130-159mg/dL (not taking cholesterol-lowering medications)
Exclusion Criteria:
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| ID | Term |
|---|---|
| D004952 | Esters |
| D012855 | Sitosterols |
| ID | Term |
|---|---|
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D002782 | Cholestenes |
| D002776 | Cholestanes |
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| Other |
|
| Change from baseline Apolipoprotein A1 at 4-week |
| at baseline and 4-week follow-up |
| Change from baseline Apolipoprotein B at 4-week | at baseline and 4-week follow-up |
| D013256 |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D010840 | Phytosterols |
| D013261 | Sterols |
| D008563 | Membrane Lipids |
| D008055 | Lipids |
| D064209 | Phytochemicals |
| D001685 | Biological Factors |