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| ID | Type | Description | Link |
|---|---|---|---|
| 2/11/15 | Other Identifier | Ethics Committee of the University Medical Center Göttingen |
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No participants
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Not only caries but also exposure to acids can lead to loss of tooth structure. This acid-related tooth structure loss is defined as dental erosion.
A relationship between dental erosion and occurence of reflux disease was shown in numerous studies. On the one hand, patients with dental erosions frequently show reflux disease. On the other hand, many - but not all - reflux patients show dental erosions. It is believed that certain salivary parameters might explain, why not all reflux patients alike are affected of dental erosions.
The aim of this study is to analyze the relationship and the extent of occurrence of dental erosions and reflux symptoms, including investigation of certain salivary parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Reflux patients | Patients who are treated at the Clinic for Gastroenterology and Gastrointestinal Oncology and have a 24-hours pH monitoring or impedance measurement performed for medical reasons |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Collection of saliva samples | Other | Collection of saliva samples |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Visual assessment of the BEWE-(basic erosive wear examination)-index | After removal of the probe (on second day) |
| Measure | Description | Time Frame |
|---|---|---|
| Determination of unstimulated and stimulated saliva flow rate (ml/min). | While wearing the probe at three time points over 24h: morning, noon, evening | |
| Determination of saliva pH and buffer capacity (mol/L). | While wearing the probe at three time points over 24h: morning, noon, evening |
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Exclusion Criteria:
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Exploratory study
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| Name | Affiliation | Role |
|---|---|---|
| Annette Wiegand, Prof. Dr. med. dent. | Dept. of Prev. Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Germany | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18228057 | Background | Bartlett D, Ganss C, Lussi A. Basic Erosive Wear Examination (BEWE): a new scoring system for scientific and clinical needs. Clin Oral Investig. 2008 Mar;12 Suppl 1(Suppl 1):S65-8. doi: 10.1007/s00784-007-0181-5. Epub 2008 Jan 29. | |
| 24993267 | Background | Hara AT, Zero DT. The potential of saliva in protecting against dental erosion. Monogr Oral Sci. 2014;25:197-205. doi: 10.1159/000360372. Epub 2014 Jun 26. |
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| ID | Term |
|---|---|
| D014077 | Tooth Erosion |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D057085 | Tooth Wear |
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Saliva samples are obtained and retained for 10 years.
| Visual detection of BEWE-index |
| Other |
Visual detection of BEWE-index |
|
| Determination of total protein content in saliva (g/L). | While wearing the probe at three time points over 24h: morning, noon, evening |
| Determination inorganic calcium and phosphate in saliva (mmol/L). | While wearing the probe at three time points over 24h: morning, noon, evening |
| Measurement of salivary enzyme activity: Protease, Kollagenase/Gelatinase, Pepsin, Trypsin, and Amylase (U/mL). | While wearing the probe at three time points over 24h: morning, noon, evening |
| 15240067 | Background | Moazzez R, Bartlett D, Anggiansah A. Dental erosion, gastro-oesophageal reflux disease and saliva: how are they related? J Dent. 2004 Aug;32(6):489-94. doi: 10.1016/j.jdent.2004.03.004. |
| 22004279 | Background | Ranjitkar S, Smales RJ, Kaidonis JA. Oral manifestations of gastroesophageal reflux disease. J Gastroenterol Hepatol. 2012 Jan;27(1):21-7. doi: 10.1111/j.1440-1746.2011.06945.x. |
| 22472533 | Background | Schlueter N, Ganss C, Potschke S, Klimek J, Hannig C. Enzyme activities in the oral fluids of patients suffering from bulimia: a controlled clinical trial. Caries Res. 2012;46(2):130-9. doi: 10.1159/000337105. Epub 2012 Apr 3. |
| 20696201 | Background | Wang GR, Zhang H, Wang ZG, Jiang GS, Guo CH. Relationship between dental erosion and respiratory symptoms in patients with gastro-oesophageal reflux disease. J Dent. 2010 Nov;38(11):892-8. doi: 10.1016/j.jdent.2010.08.001. Epub 2010 Aug 7. |
| 25922678 | Background | Wilder-Smith CH, Materna A, Martig L, Lussi A. Gastro-oesophageal reflux is common in oligosymptomatic patients with dental erosion: A pH-impedance and endoscopic study. United European Gastroenterol J. 2015 Apr;3(2):174-81. doi: 10.1177/2050640614550852. |
| 27022647 | Background | Kanzow P, Wegehaupt FJ, Attin T, Wiegand A. Etiology and pathogenesis of dental erosion. Quintessence Int. 2016 Apr;47(4):275-8. doi: 10.3290/j.qi.a35625. |