A Study of Tooth Erosion in People With Esophagogastric Cancer

Pilot Study of Dental Erosion as a Non-invasive Biomarker of Esophagogastric Cancer

The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer, pancreatic cancer, breast cancer, head and neck cancer, or non-small cell lung cancer, or a healthy volunteer.

Inclusion Criteria:

• Subject is willing and able to provide written informed consent.
• Patients with a history of esophagogastric, HNSCC, PDAC, CRC, or NSCLC or healthy controls
• Patients must be able to fully comprehend and complete the survey and be willing to have pictures taken of their teeth with a camera or intra-oral camera.
• Patients must be able to understand English language or have access to adequate translation services.
• Age ≥ 18 years old.

Exclusion Criteria:

• Subjects without evaluable molars or with significant molar dental work precluding dentists from assessing enamel status, Note: evaluable is defined as having bilateral assessable mandibular molars, or erosions present in the remaining assessable quadrants.
• For healthy controls only, patients cannot have a non-skin cancer history nor presenting for a procedure evaluating reflux symptoms.