Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome

Effects of Propofol and Sevoflurane on Early Postoperative Cognitive Dysfunction in Elderly Patients With Metabolic Syndrome

The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Inclusion Criteria:

• aged ≥60 years;
• ASAⅡor Ⅲ
• noncardiac surgery and nonneural surgery

Exclusion Criteria:

• Mini Mental State Examination [MMSE] score too low
• chronic alcoho and drug abuse
• disturbed renal and liver function
• history of a cerebrovascular accident
• permanent ventricular pacing
• preoperative cognitive deficits
• lack of cooperation