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According to the inclusion and exclusion criteria, elderly patients undergoing elective orthopedic surgery were randomly divided into four groups. The different combinations of propofol and sevoflurane were used in the four groups: 1 day before surgery, after patients become wide-awake, and 3 days, 7 days, and 3 months after surgery, the patient's cognitive function was evaluated using a professional cognitive scale and other indicators. Finally, statistical analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol | Experimental | administrated Target Controlled Infusion （TCI）of propofol （Cp 2.0~2.5μg/ml ）for maintaining |
|
| 1.2 μg/ml Propofol | Experimental | administrated Target Controlled Infusion （TCI）of propofol （Cp 1.2 μg/ml ）combined with appropriate sevoflurane for maintaining |
|
| 0.6 μg/ml Propofol | Experimental | administrated Target Controlled Infusion （TCI）of propofol （Cp 0.6 μg/ml ）combined with appropriate sevoflurane for maintaining |
|
| Sevoflurane | Experimental | administrated 1.3 minimum alveolar concentration（MAC ） sevoflurane for maintaining |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol | Drug | Propofol is the most common clinical anesthetics. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evidence of clinically cognitive function decline ：Apolipoprotein J（ApoJ） | Measurement by ELISA kit | Change from Baseline Apolipoprotein J at 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Evidence of clinically cognitive function decline ：Soluble CD14（sCD14） | Estimating by ELISA kit | Change from Baseline Soluble CD14 at 7 days |
| Mini mental Examination(MMSE) | A questionnaires is used to assess the cognitive function of patients in clinical.Total range was 0~30，≦27 were considered as cognitive function decline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Haiyun Wang | Contact | 86-13752211206 | why@126.com | |
| Yimeng Chen | Contact | chenyimeng5525@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Third Central Hospital of Tianjin | Recruiting | Tianjin | Tianjin Municipality | 022 | China |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Sevoflurane | Drug | Sevoflurane is the most common clinical anesthetics. |
|
| preoperative 24 hours ， 7 days post surgery |
| Montreal Cognitive Assessment（MoCA) | A questionnaires is used to assess the cognitive function of patients in clinical.Total range was 0~30，≦27 were considered as cognitive function decline. | preoperative 24 hours ，7 days post surgery |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |