POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

Incidence of Postoperative Cognitive Dysfunction in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia: A Randomized, Controlled Trial

The use of desflurane in elderly subjects (>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.

Inclusion Criteria:

• Adult patients (>65 years old)
• Scheduled for elective surgery requiring general anesthesia at LLUMC HSH
• Airway management expected to include endotracheal intubation
• Expected surgical duration 120 to 240 minutes

Exclusion Criteria:

• Pre-existing significant psychiatric disease or mental status changes

• Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease

• Patient's weighing >50% ideal body weight

  • Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet
  • Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet

• Patients who have undergone a general anesthetic within the past 7 days

• Patient refusal