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| Name | Class |
|---|---|
| Ontario Ministry of Health and Long Term Care | OTHER_GOV |
| Heart and Stroke Foundation of Canada | OTHER |
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Coronary revascularization improves survival for patients with coronary artery disease. However,many patients are left with poor physical and mental health. Traditional cardiac rehabilitation involves moderate intensity continuous exercise (MICE). Alternatives to traditional cardiac rehabilitation programming may however provide superior understudied benefits to patients with poor physical and mental health. Nordic walking (NW) and high-intensity interval training (HIIT) are two examples of alternative programs for cardiac rehabilitation, which may provide superior physical and mental health benefits when compared to traditional MICE. The main purpose of this project is, therefore, to determine the short and long term physical and mental health benefits of alternative cardiac rehabilitation modalities, including NW and HIIT on exercise capacity, quality of life and depression after a 12-week program.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Moderate Intensity Continuous Exercise | Experimental | Moderate Intensity Continuous Exercise Training |
|
| Nordic Walking | Experimental | Nordic Walking |
|
| High Intensity Interval Training | Experimental | High Intensity Interval Training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Intensity Interval Training | Behavioral | Participants will complete supervised exercise sessions. Participants will attend on-site high-intensity interval training two times weekly for 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Exercise Capacity | Changes in exercise capacity from baseline to 12 weeks and baseline to 26 weeks are measured by the six-minute walk test | Baseline to 12 weeks and Baseline to 26 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Functional Fitness | Changes in functional fitness from baseline to 12 weeks and baseline to 26 weeks are measured by the Senior Fitness Test | Baseline to 12 weeks and Baseline to 26 weeks |
| Aortic stiffness |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jennifer L Reed, PhD | Ottawa Heart Institute Research Corporation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Ottawa Heart Insititue | Ottawa | Ontario | K1Y 4W7 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37184470 | Derived | Marcal IR, Cotie LM, Ribeiro I, Reed JL. The Effects of Different Exercise Modalities and Intensities on Arterial Stiffness in Patients With Coronary Artery Disease. J Cardiopulm Rehabil Prev. 2023 Sep 1;43(5):384-385. doi: 10.1097/HCR.0000000000000799. Epub 2023 May 15. No abstract available. | |
| 36905198 | Derived |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jun 11, 2026 | |
| Reset | Jul 8, 2026 |
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|
| Moderate Intensity Continuous Exercise Training | Behavioral | Participants will complete supervised exercise sessions. Moderate-intensity continuous exercise training will follow cardiovascular rehabilitation guidelines. Participants will attend on-site moderate-intensity continuous exercise training two times weekly for 12 weeks. |
|
|
| Nordic Walking | Behavioral | Participants will complete supervised exercise sessions. Participants will attend on-site Nordic walking training two times weekly for 12 weeks |
|
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Changes in aortic stiffness from baseline to 12 weeks and baseline to 26 weeks are measured by pulse wave velocity
| Baseline to 12 weeks and Baseline to 26 weeks |
| Body Composition | Changes in body composition from baseline to 12 weeks and baseline to 26 weeks are measured by the waist circumference. | Baseline to 12 weeks and Baseline to 26 weeks |
| Body Composition | Changes in body composition from baseline to 12 weeks and baseline to 26 weeks are measured by bioelectrical impedance. | Baseline to 12 weeks and Baseline to 26 weeks |
| Body Composition | Changes in body composition from baseline to 12 weeks and baseline to 26 weeks are measured by body mass index. | Baseline to 12 weeks and Baseline to 26 weeks |
| Depression | Changes in depression from baseline to 12 weeks and baseline to 26 weeks are measured by the Beck Depression Inventory-II questionnaire | Baseline to 12 weeks and Baseline to 26 weeks |
| Quality of Life - SF36 | Changes in quality of life from baseline to 12 weeks and baseline to 26 weeks are measured by the Short Form-36. | Baseline to 12 weeks and Baseline to 26 weeks |
| Quality of Life - HeartQoL | Changes in quality of life from baseline to 12 weeks and baseline to 26 weeks are measured by the HeartQoL questionnaire | Baseline to 12 weeks and Baseline to 26 weeks |
| Exercise Adherence | Changes in exercise adherence from baseline to 12 weeks and baseline to 26 weeks are measured by the Actigraph accelerometer | Baseline to 12 weeks and Baseline to 26 weeks |
| Depression mechanisms | Changes in depression mechanisms from baseline to 12 weeks and baseline to 26 weeks are measured by plasma brain derived neurotrophic factor. | Baseline to 12 weeks and Baseline to 26 weeks |
| Depression mechanisms | Changes in depression mechanisms from baseline to 12 weeks and baseline to 26 weeks are measured by plasma irisin. | Baseline to 12 weeks and Baseline to 26 weeks |
| Depression mechanisms | Changes in depression mechanisms from baseline to 12 weeks and baseline to 26 weeks are measured by plasma kynurenine. | Baseline to 12 weeks and Baseline to 26 weeks |
| Lipid and glucose profile | Changes in lipid and glucose profile from baseline to 12 weeks and baseline to 26 weeks are measured by plasma total cholesterol. | Baseline to 12 weeks and Baseline to 26 weeks |
| Lipid and glucose profile | Changes in lipid and glucose profile from baseline to 12 weeks and baseline to 26 weeks are measured by plasma Low Density Lipoprotein | Baseline to 12 weeks and Baseline to 26 weeks |
| Lipid and glucose profile | Changes in lipid and glucose profile from baseline to 12 weeks and baseline to 26 weeks are measured by plasma High Density Lipoprotein. | Baseline to 12 weeks and Baseline to 26 weeks |
| Lipid and glucose profile | Changes in lipid and glucose profile from baseline to 12 weeks and baseline to 26 weeks are measured by plasma Hemoglobin A1c | Baseline to 12 weeks and Baseline to 26 weeks |
| Garneau L, Terada T, Mistura M, Mulvihill EE, Reed JL, Aguer C. Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study. Physiol Rep. 2023 Mar;11(5):e15634. doi: 10.14814/phy2.15634. |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 11, 2026 | Jul 8, 2026 |
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| D000088783 | Nordic Walking |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D016138 | Walking |
| D008124 | Locomotion |
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