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This randomized controlled trial aims to compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after coronary artery disease or post-angioplasty. A total of 66 participants will be randomly allocated into two groups: HIIT (n=33) and MICT (n=33). The intervention will be conducted 3 times per week using treadmill-based exercise protocols under heart rate monitoring. Primary outcomes include changes in left ventricular ejection fraction, functional capacity measured by 6-minute walk test, and lipid profile parameters before and after intervention. Secondary assessment includes health-related quality of life (HRQoL). The study aims to determine which exercise modality provides superior cardiovascular and functional improvement in stable cardiac patients during supervised rehabilitation.
This randomized controlled trial will compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after stable coronary artery disease or post-angioplasty. A total of 66 participants will be randomly assigned into two groups.
The HIIT group will perform treadmill-based interval exercise 3 times per week at 85-95% heart rate reserve with active recovery periods, while the MICT group will perform continuous treadmill exercise at 65-75% heart rate reserve for 30-45 minutes.
Primary outcomes include left ventricular ejection fraction (echocardiography), functional capacity (6-minute walk test), and lipid profile (LDL, HDL, triglycerides, total cholesterol) measured before and after intervention. Health-related quality of life (HRQoL) will also be assessed. The study aims to determine which exercise protocol produces greater improvement in cardiac and functional outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-Intensity Interval Training (HIIT) | Experimental | Participants will perform supervised treadmill-based high-intensity interval training 3 sessions per week, including 10-minute warm-up, 4 intervals of 4 minutes at 85-95% heart rate reserve, 4-minute active recovery at 50-60% heart rate reserve, followed by 5-minute cool-down. |
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| Moderate-Intensity Continuous Training (MICT) | Active Comparator | Participants will perform supervised treadmill-based continuous exercise 3 sessions per week at 65-75% heart rate reserve for 30-45 minutes, with warm-up and cool-down periods. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-Intensity Interval Training | Behavioral | Participants will perform supervised treadmill-based high-intensity interval training 3 times per week. Each session includes 10 minutes warm-up, 4 intervals of 4 minutes at 85-95% heart rate reserve, 4 minutes active recovery at 50-60% heart rate reserve, followed by 5 minutes cool-down. |
| Measure | Description | Time Frame |
|---|---|---|
| Left Ventricular Ejection Fraction | Assessment of left ventricular ejection fraction using echocardiography to determine changes in cardiac function after intervention. | Baseline and at 12 weeks after intervention |
| Functional Capacity | Functional capacity will be measured by 6-minute walk test to evaluate distance covered during exercise tolerance assessment | Baseline and at 12 weeks after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Lipid Profile | Laboratory measurement of total cholesterol, LDL, HDL, and triglycerides to assess metabolic changes after exercise intervention. | Baseline and at 12 weeks after intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Muhammad Iqbal Tariq, Phd* | Contact | 333826752 | iqbal.tariq@riphah.edu.pk |
| Name | Affiliation | Role |
|---|---|---|
| Arjumand Bano, MSPT | Riphah International University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ch Pervaiz Elahi institute of cardiology Multan. | Multan | Punjab Province | 60000 | Pakistan |
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Participants will be randomly assigned into two parallel groups: one group will receive High-Intensity Interval Training (HIIT) and the other group will receive Moderate-Intensity Continuous Training (MICT). Both groups will receive supervised treadmill-based exercise interventions during Phase II cardiac rehabilitation, and outcomes will be compared before and after intervention.
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This study is open-label because both participants and care providers are aware of the assigned exercise intervention. Outcome measurements will be recorded using standardized assessment tools including echocardiography, laboratory investigations, and 6-minute walk test.
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| Moderate-Intensity Continuous Training | Behavioral | Participants will perform supervised treadmill-based continuous exercise 3 times per week at 65-75% heart rate reserve for 30-45 minutes, including warm-up and cool-down periods. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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