ProAliFun_6.5_Health Effects of a Functional Pasta Enriched With Barley Beta-glucans on Healthy Subjects

Technological and Clinical Innovative Protocols for the Production of Functional Foods - 6.5 (ProAliFun65)

The purpose of this study is to evaluate the healthy properties of a dietary intervention based on an innovative pasta enriched with prebiotic fibers (barley beta-glucans).

The hypothesis is that the gut microbiota and metabolome, the nutritional status, the redox/subclinical inflammation parameters and the markers of cardiovascular risk may improve in healthy subjects.

This clinical trial is a prospective pilot study, lasting 4 months. A target number of 30 healthy individuals meeting inclusion and exclusion criteria, assessed at enrollment, and which have signed the informed consent, will be recruited.

Inclusion Criteria:

• healthy subjects
• aged between 30 and 70 years
• BMI between 18.5 and 24.9
• omnivorous diet
• informed consent signed

Exclusion Criteria:

• diabetes type 2
• urine protein > 1g/24h
• antibiotics and probiotics administration by 15 days before the enrollment
• gastrointestinal, celiac, inflammatory systemic and chronic liver diseases
• recent diagnosis of cancer
• corticosteroid or immunosuppressive therapies
• previous major acute cardiovascular pathologies (heart attack, cerebral ictus)
• hyperlipidemia
• consume of alcohol
• psychiatric diseases