Effects of Two Doses of Thylakoids on OGTT

Thylakoids' Effect on Glucose Homeostasis and Appetite Regulation After an Oral Glucose Tolerance Test in Healthy Volunteers

This cross-over intervention study aims to investigate the effect of two doses of thylakoids to an oral glucose tolerance test (OGTT) on glucose and insulin homeostasis as well as appetite regulating hormones in healthy volunteers.

A minimum of twenty healthy volunteers are recruited to participate in an OGTT at three different occasions separated by one week. At two of the occasions a green leaf extract, thylakoids, is added to a glucose solution; 5 gram or 10 gram in randomized order. The third occasion, without added thylakoids, serve as control.

Blood samples are taken fasting and 15, 30, 45, 60, 90, 120 and 180 minutes after the glucose load.

Blood samples are analysed for p-glucose, p-insulin, p-C-peptide, p-ghrelin, p-CCK and p-GLP-1.

Inclusion Criteria:

• Healthy
• Adult
• Normal-weight and weight stable
• Not pregnant or breast-feeding
• No use of medication that can affect glucose- and insulin homeostasis (for example corticosteroids).

Exclusion Criteria:

• Diabetes,
• Impaired glucose tolerance and/or insulin resistance
• Anaemia
• Use of tobacco or drugs.