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| Name | Class |
|---|---|
| Aspect Clinical | UNKNOWN |
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The main aim of the study is to investigate the effects of dietary ingredients (polyphenols and carotenoids) on vascular function during acute glucose load. Each subject will receive 4 weeks of intervention with test product or placebo product after a dietary restriction run-in period of 14 days. Subjects will be challenged with an oral glucose tolerance test (OGTT) immediately after the run-in phase and at the end of the intervention phase. During the OGTT, blood samples will be taken at regular intervals.
The study will be conducted in subjects with impaired glucose tolerance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dietary ingredients: polyphenols and carotenoids | Active Comparator | Dietary ingredients: polyphenols and carotenoids |
|
| Placebo product | Placebo Comparator | Placebo product |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| A capsule containing both polyphenols and carotenoids | Dietary Supplement |
| ||
| Placebo intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Interleukin-6 (IL-6) levels. | At baseline (after 2 weeks run-in period) and after 4 weeks intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Pro-inflammatory and oxidative stress biomarkers |
| At baseline (after 2 weeks run-in period) and after 4 weeks intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alex Thompson, Dr | Aspect Clinical | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aspect Clinical | Ledbury | United Kingdom |
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| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D018149 | Glucose Intolerance |
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D006943 | Hyperglycemia |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D002338 | Carotenoids |
| ID | Term |
|---|---|
| D011090 | Polyenes |
| D000475 | Alkenes |
| D006839 | Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
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| Dietary Supplement |
Placebo intervention |
|
| Cell stress-defence responses |
| At baseline (after 2 weeks run-in period) and after 4 weeks intervention |
| Clinical chemistry parameters |
| At baseline (after run-in period of 2 weeks) and after 4 weeks intervention |
| D009750 |
| Nutritional and Metabolic Diseases |
| D009930 |
| Organic Chemicals |
| D053138 | Cyclohexenes |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D013729 | Terpenes |
| D010860 | Pigments, Biological |
| D001685 | Biological Factors |