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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-0012 | Other Grant/Funding Number | IRSST |
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| Name | Class |
|---|---|
| Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail | OTHER |
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In Quebec, thousands of workers are concomitantly exposed to heat and chemical compounds. Exposure to heat induces physiological responses that help maintaining a stable body temperature. Those changes can affect organ functions implicated in absorption and metabolism. According to literature, those changes could lead to increased concentrations of chemical compounds in the body and their toxicity. Therefore, the aim of this study is to evaluate the pulmonary absorption and toxicokinetics of 3 organic solvents in heat stress conditions in volunteers exposed in a inhalation chamber. Results will then be used to develop PBPK models that will allow to predict organic solvent kinetics when coexposed with heat.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Heat stress | Experimental | 4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Heat stress (21) | Other | 4h exposure to heat (WBGT of 21°C), no solvent |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory rate | Respiratory rate will be monitored continuously for 4hour with a respirometer | 4hour |
| Cardiac frequency | Cardiac frequency will be monitored continuously for 4hour with a respirometer | 4hour |
| Minute ventilation | Minute ventilation will be monitored continuously for 4hour with a respirometer | 4hour |
| Tidal volume | Tidal volume will be monitored continuously for 4hour with a respirometer | 4hour |
| Solvent in blood | Solvents concentrations will be measured in blood samples collected at different times (t=0, 2, 4 and 4.5hour). | 4,5hour |
| Solvent or metabolite in urine | Solvent or metabolite concentrations (o-cresol for toluene exposures) will be measured for urine samples collected at different times (t=0, 4, 10 and 18hour). | 18hour |
| Solvent in exhaled air | Solvents concentrations will be measured in exhaled air samples collected at different times (t=0, 1.5, 3, 4.5 and 6hour). | 6hour |
| Measure | Description | Time Frame |
|---|---|---|
| Oxygen consumption | oxygen consumption will be monitored continuously for 4hour with a respirometer | 4hour |
| Carbonic dioxide production | carbonic dioxide production will be monitored continuously for 4hour with a respirometer |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sami Haddad, Ph.D | Contact | 514-343-6111 | 38166 | sami.haddad@umontreal.ca |
| Name | Affiliation | Role |
|---|---|---|
| Sami Haddad, Ph.D | Université de Montréal | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Université de Montréal | Recruiting | Montreal | Quebec | H3T 1J4 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38127129 | Derived | Marchand A, Menard J, Brochu P, Haddad S. Modeling the impact of heat stress on the toxicokinetics of toluene and acetone. Arch Toxicol. 2024 Feb;98(2):471-479. doi: 10.1007/s00204-023-03646-6. Epub 2023 Dec 21. |
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| Heat stress (25) |
| Other |
4h exposure to heat (WBGT of 25°C), no solvent |
|
| Heat stress (30) | Other | 4h exposure to heat (WBGT of 30°C), no solvent |
|
| Heat Stress (21) +TOL | Other | 4h exposure to heat (WBGT of 21°C) + Toluene (concentration = TLV) |
|
| Heat stress (25) + TOL | Other | 4h exposure to heat (WBGT of 25°C) + Toluene (concentration = TLV) |
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| Heat stress (21) + TOL | Other | 4h exposure to heat (WBGT of 30°C) + Toluene (concentration = TLV) |
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| Heat stress (21) + ACE | Other | 4h exposure to heat (WBGT of 21°C) + Acetone (concentration = TLV) |
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| Heat stress (25) + ACE | Other | 4h exposure to heat (WBGT of 25°C) + Acetone (concentration = TLV) |
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| Heat stress (30) + ACE | Other | 4h exposure to heat (WBGT of 30°C) + Acetone (concentration = TLV) |
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| Heat stress (21) + DCM | Other | 4h exposure to heat (WBGT of 21°C) + Dichloromethane (concentration = TLV) |
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| Heat stress (25) + DCM | Other | 4h exposure to heat (WBGT of 25°C) + Dichloromethane (concentration = TLV) |
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| Heat stress (30) + DCM | Other | 4h exposure to heat (WBGT of 30°C) + Dichloromethane (concentration = TLV) |
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| Heat stress (21) + TOL (dermal) | Other | 4h exposure to heat (WBGT of 21°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption. |
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| Heat stress (25) + TOL (dermal) | Other | 4h exposure to heat (WBGT of 25°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption. |
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| Heat stress (30) + TOL (dermal) | Other | 4h exposure to heat (WBGT of 30°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption. |
|
| 4hour |
| Body temperature | Body temperature is monitored continuously by telemetry | 4hour |
| ID | Term |
|---|---|
| D018869 | Heat-Shock Response |
| C004763 | 3',5'-dichloromethotrexate |
| D000279 | Administration, Cutaneous |
| ID | Term |
|---|---|
| D013312 | Stress, Physiological |
| D010829 | Physiological Phenomena |
| D000287 | Administration, Topical |
| D004333 | Drug Administration Routes |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
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