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Workplaces rely on upper heat stress limits provided by the American Conference of Governmental Industrial Hygienists (ACGIH) to manage the health and safety of workers in hot environments. This is primarily achieved by interspersing work with rest periods, the length of which is dictated by environmental conditions and work intensity, to maintain core temperature at or below 38.0°C (equivalent to a 1°C increase in body core temperature above resting levels). However, these guidelines employ a "one size fits all" approach to exposure limits that does not consider individual variation between workers. Moreover, they fail to provide direction on the safe, initial stay times before these heat-mitigation controls should be employed (i.e., rest breaks) in conditions exceeding upper heat stress limits. While recent work has generated estimates of the initial stay times for young to older men before heat-mitigation controls are required for moderate-intensity work, this information is limited to a single work bout and does not consider a second work bout preceded by an extended rest period (e.g., lunch) or next day effects. This is a key consideration, as prolonged work in the heat has been shown to cause next-day impairments in heat dissipation in older men. Further, it remains unclear if the application of the prescribed ACGIH work-rest allocations thereafter would alleviate increases in core temperature for the duration of the work period (e.g., start of shift versus post-lunch period). This project will address these knowledge gaps by determining if refinements in initial stay times for moderate-intensity work (represents the average work effort of physically demanding occupations) in the heat (26°C wet-bulb globe temperature) may be required for young and older adults for i) a second work bout that is preceded by an extended rest period such as a lunch break, and ii) a work bout performed on the next day. This includes assessing the efficacy of the prescribed ACGIH work-rest allocations to mitigate increases in core temperature beyond safe limits (>38.0°C, equivalent to a >1°C increase in body core temperature above resting levels) during these work periods. Given the known sex-differences in heat loss that can modulate core temperature regulation during an exercise-heat stress, the investigators will conduct separate analysis to identify modulating effects of biological sex on the initial stay times and effectiveness of the work-rest allocation as a heat-alleviation control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Younger adults | Experimental | Adults aged 18-30 years with no pre-existing health conditions |
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| Older adults | Experimental | Adults aged 50-69 with no pre-existing health conditions |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Simulated work in the heat | Other | Participants perform a continuous moderate-intensity work bout (metabolic rate of ~200 W/m2) until core temperature reaches 38.0°C (equivalent to a 1°C increase in body core temperature above resting levels), which is immediately followed by intermittent work using a 3:1 work-rest allocation, starting with a 15 min rest break followed by a 45 min work bout for a total work duration of ~240 min. The work protocol is performed in the morning of day 1, and repeated in a post-lunch work period (i.e., afternoon of day 1) and on the morning of the next day (i.e., morning of day 2). |
| Measure | Description | Time Frame |
|---|---|---|
| Initial stay time | Total continuous work time to achieve an initial absolute increase in core temperature of 38°C (equivalent to a 1°C increase in body core temperature above resting levels) (note: in instances where a participant voluntarily terminates work prematurely before the absolute core temperature of ≥38°C (or relative increase of ≥1°C) is achieved or the absolute core temperature is <38°C (or relative increase of <1°C), the time of termination or end of the work bout will be taken as the initial stay time respectively). | End of first (morning day 1) continuous work bout |
| Initial stay time | Total continuous work time to achieve an initial absolute increase in core temperature of 38°C (equivalent to a 1°C increase in body core temperature above resting levels) (note: in instances where a participant voluntarily terminates work prematurely before the absolute core temperature of ≥38°C (or relative increase of ≥1°C) is achieved or the absolute core temperature is <38°C (or relative increase of <1°C), the time of termination or end of the work bout will be taken as the initial stay time respectively). | End of second (afternoon day 1) continuous work bout |
| Initial stay time | Total continuous work time to achieve an initial absolute increase in core temperature of 38°C (equivalent to a 1°C increase in body core temperature above resting levels) (note: in instances where a participant voluntarily terminates work prematurely before the absolute core temperature of ≥38°C (or relative increase of ≥1°C) is achieved or the absolute core temperature is <38°C (or relative increase of <1°C), the time of termination or end of the work bout will be taken as the initial stay time respectively). | End of third (morning day 2) continuous work bout |
| Average core temperature | Average core temperature over final 2-hours of each work bout | Period of work-rest allocations following initial stay time for morning day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate at initial stay time | Heart rate at the initial increase in absolute core temperature of 38°C (or relative increase of 1°C) | End of first (morning day 1) continuous work bout |
| Heart rate at initial stay time |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Glen P Kenny, PhD | University of Ottawa | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Ottawa | Ottawa | Ontario | K1N6N5 | Canada |
Deidentified participant data will be made available with approved analysis plan and signed access agreement
Following publication of the main study report(s)
Approved analysis plan and signed access agreement
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| ID | Term |
|---|---|
| D018882 | Heat Stress Disorders |
| D009043 | Motor Activity |
| D003075 | Coitus |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D001519 | Behavior |
| D012725 | Sexual Behavior |
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Data will be blinded prior to analysis
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| Average core temperature | Average core temperature following initial stay time | Period of work-rest allocations following initial stay time for afternoon day 1 |
| Average core temperature | Average core temperature following initial stay time | Period of work-rest allocations following initial stay time for morning day 2 |
Heart rate at the initial increase in absolute core temperature of 38°C (or relative increase of 1°C)
| End of second (afternoon day 1) continuous work bout |
| Heart rate at initial stay time | Heart rate at the initial increase in absolute core temperature of 38°C (or relative increase of 1°C) | End of third (morning day 2) continuous work bout |
| Average heart rate | Average heart rate following initial stay time | Period of work-rest allocations following initial stay time for morning day 1 |
| Average heart rate | Average heart rate following initial stay time | Period of work-rest allocations following initial stay time for afternoon day 1 |
| Average heart rate | Average heart rate following initial stay time | Period of work-rest allocations following initial stay time for morning day 2 |
| Skin temperature at initial stay time | Skin temperature (4 sites) measured at the initial increase in absolute core temperature of 38°C (or relative increase of 1°C) | End of first (morning day 1) continuous work bout |
| Skin temperature at initial stay time | Skin temperature (4 sites) measured at the initial increase in absolute core temperature of 38°C (or relative increase of 1°C) | End of second (afternoon day 1) continuous work bout |
| Skin temperature at initial stay time | Skin temperature (4 sites) measured at the initial increase in absolute core temperature of 38°C (or relative increase of 1°C) | End of third (morning day 2) continuous work bout |
| Average skin temperature | Average skin temperatures following initial stay time | Period of work-rest allocations following initial stay time for morning day 1 |
| Average skin temperature | Average skin temperatures following initial stay time | Period of work-rest allocations following initial stay time for afternoon day 1 |
| Average skin temperature | Average skin temperatures following initial stay time | Period of work-rest allocations following initial stay time for morning day 2 |
| Systolic blood pressure | Arterial blood pressure measured via automated oscillometry | End of first (morning day 1) work period |
| Systolic blood pressure | Arterial blood pressure measured via automated oscillometry | End of second (afternoon day 1) work period |
| Systolic blood pressure | Arterial blood pressure measured via automated oscillometry | End of third (morning day 2) work period |
| Diastolic blood pressure | Arterial blood pressure measured via automated oscillometry | End of first (morning day 1) work period |
| Diastolic blood pressure | Arterial blood pressure measured via automated oscillometry | End of second (afternoon day 1) work period |
| Diastolic blood pressure | Arterial blood pressure measured via automated oscillometry | End of third (morning day 2) work period |
| Mean arterial blood pressure | Calculated as 1/3 * systolic blood pressure + 2/3 * diastolic blood pressure | End of first (morning day 1) work period |
| Mean arterial blood pressure | Calculated as 1/3 * systolic blood pressure + 2/3 * diastolic blood pressure | End of second (afternoon day 1) work period |
| Mean arterial blood pressure | Calculated as 1/3 * systolic blood pressure + 2/3 * diastolic blood pressure | End of third (morning day 2) work period |
| Rate pressure product | Calculated as systolic blood pressure * heart rate | End of first (morning day 1) work period |
| Rate pressure product | Calculated as systolic blood pressure * heart rate | End of second (afternoon day 1) work period |
| Rate pressure product | Calculated as systolic blood pressure * heart rate | End of third (morning day 2) work period |
| Fluid consumption | Cumulative fluid consumption calculated by weighing the participant's water intake | End of first (morning day 1) work period |
| Fluid consumption | Cumulative fluid consumption calculated by weighing the participant's water intake | End of second (afternoon day 1) work period |
| Fluid consumption | Cumulative fluid consumption calculated by weighing the participant's water intake | End of third (morning day 2) work period |
| Fluid loss | Fluid loss calculated as the change in body mass (corrected for food/fluid consumption). | End of first (morning day 1) work period |
| Fluid loss | Fluid loss calculated as the change in body mass (corrected for food/fluid consumption). | End of second (afternoon day 1) work period |
| Fluid loss | Fluid loss calculated as the change in body mass (corrected for food/fluid consumption). | End of third (morning day 2) work period |
| Change in plasma volume | Determined from venous blood samples | End of first (morning day 1) work period |
| Change in plasma volume | Determined from venous blood samples | End of second (afternoon day 1) work period |
| Change in plasma volume | Determined from venous blood samples | End of third (morning day 2) work period |
| Thermal comfort scale | Thermal comfort assessed via a visual analog scale ("How comfortable does your body temperature feel?") (4: very uncomfortable to 1: comfortable) | End of first (morning day 1) continuous work bout |
| Thermal comfort scale | Thermal comfort assessed via a visual analog scale ("How comfortable does your body temperature feel?") (4: very uncomfortable to 1: comfortable) | End of second (afternoon day 1) continuous work bout |
| Thermal comfort scale | Thermal comfort assessed via a visual analog scale ("How comfortable does your body temperature feel?") (4: very uncomfortable to 1: comfortable) | End of third (morning day 2) continuous work bout |
| Thermal comfort scale | Thermal comfort assessed via a visual analog scale ("How comfortable does your body temperature feel?") (4: very uncomfortable to 1: comfortable) | Period of work-rest allocations following initial stay time for morning day 1 |
| Thermal comfort scale | Thermal comfort assessed via a visual analog scale ("How comfortable does your body temperature feel?") (4: very uncomfortable to 1: comfortable) | Period of work-rest allocations following initial stay time for afternoon day 1 |
| Thermal comfort scale | Thermal comfort assessed via a visual analog scale ("How comfortable does your body temperature feel?") (4: very uncomfortable to 1: comfortable) | Period of work-rest allocations following initial stay time for morning day 2 |
| Thirst sensation scale | Assessed via a visual analog scale ("How thirsty are you?") (9: very, very thirsty to 1: Not thirsty at all) | End of first (morning day 1) continuous work bout |
| Thirst sensation scale | Assessed via a visual analog scale ("How thirsty are you?") (9: very, very thirsty to 1: Not thirsty at all) | End of second (afternoon day 1) continuous work bout |
| Thirst sensation scale | Assessed via a visual analog scale ("How thirsty are you?") (9: very, very thirsty to 1: Not thirsty at all) | End of third (morning day 2) continuous work bout |
| Thirst sensation scale | Assessed via a visual analog scale ("How thirsty are you?") (9: very, very thirsty to 1: Not thirsty at all) | Period of work-rest allocations following initial stay time for morning day 1 |
| Thirst sensation scale | Assessed via a visual analog scale ("How thirsty are you?") (9: very, very thirsty to 1: Not thirsty at all) | Period of work-rest allocations following initial stay time for afternoon day 2 |
| Thirst sensation scale | Assessed via a visual analog scale ("How thirsty are you?") (9: very, very thirsty to 1: Not thirsty at all) | Period of work-rest allocations following initial stay time for morning day 2 |
| Rating of Perceived Exertion | Perceived exertion assessed via a self-report questionnaire upon verbal prompting (6: no exertion at all to 20: maximal exertion). | End of first (morning day 1) continuous work bout |
| Rating of Perceived Exertion | Perceived exertion assessed via a self-report questionnaire upon verbal prompting (6: no exertion at all to 20: maximal exertion). | End of second (afternoon day 1) continuous work bout |
| Rating of Perceived Exertion | Perceived exertion assessed via a self-report questionnaire upon verbal prompting (6: no exertion at all to 20: maximal exertion). | End of third (morning day 2) continuous work bout |
| Rating of Perceived Exertion | Perceived exertion assessed via a self-report questionnaire upon verbal prompting (6: no exertion at all to 20: maximal exertion). | Period of work-rest allocations following initial stay time for morning day 1 |
| Rating of Perceived Exertion | Perceived exertion assessed via a self-report questionnaire upon verbal prompting (6: no exertion at all to 20: maximal exertion). | Period of work-rest allocations following initial stay time for afternoon day 2 |
| Rating of Perceived Exertion | Perceived exertion assessed via a self-report questionnaire upon verbal prompting (6: no exertion at all to 20: maximal exertion). | Period of work-rest allocations following initial stay time for morning day 2 |
| Orthostatic Intolerance Symptoms Assessment | Cumulative sum of scores on 6 questions asking participant to rank symptoms associated with orthostatic intolerance. All symptoms scored on a scale from 0 (none) to 10 (worst possible) and include feelings of: (1) "dizziness, lightheadedness, feeling faint, or feeling like you might black out"; (2) "Problems with vision (blurring, seeing spots, tunnel vision, etc.)"; (3) "Weakness"; (4) "Fatigue"; (5) "Trouble concentrating"; and (6) "Head and neck discomfort". | End of first (morning day 1) continuous work bout |
| Orthostatic Intolerance Symptoms Assessment | Cumulative sum of scores on 6 questions asking participant to rank symptoms associated with orthostatic intolerance. All symptoms scored on a scale from 0 (none) to 10 (worst possible) and include feelings of: (1) "dizziness, lightheadedness, feeling faint, or feeling like you might black out"; (2) "Problems with vision (blurring, seeing spots, tunnel vision, etc.)"; (3) "Weakness"; (4) "Fatigue"; (5) "Trouble concentrating"; and (6) "Head and neck discomfort". | End of second (afternoon day 1) continuous work bout |
| Orthostatic Intolerance Symptoms Assessment | Cumulative sum of scores on 6 questions asking participant to rank symptoms associated with orthostatic intolerance. All symptoms scored on a scale from 0 (none) to 10 (worst possible) and include feelings of: (1) "dizziness, lightheadedness, feeling faint, or feeling like you might black out"; (2) "Problems with vision (blurring, seeing spots, tunnel vision, etc.)"; (3) "Weakness"; (4) "Fatigue"; (5) "Trouble concentrating"; and (6) "Head and neck discomfort". | End of third (morning day 2) continuous work bout |
| Orthostatic Intolerance Symptoms Assessment | Cumulative sum of scores on 6 questions asking participant to rank symptoms associated with orthostatic intolerance. All symptoms scored on a scale from 0 (none) to 10 (worst possible) and include feelings of: (1) "dizziness, lightheadedness, feeling faint, or feeling like you might black out"; (2) "Problems with vision (blurring, seeing spots, tunnel vision, etc.)"; (3) "Weakness"; (4) "Fatigue"; (5) "Trouble concentrating"; and (6) "Head and neck discomfort". | Period of work-rest allocations following initial stay time for morning day 1 |
| Orthostatic Intolerance Symptoms Assessment | Cumulative sum of scores on 6 questions asking participant to rank symptoms associated with orthostatic intolerance. All symptoms scored on a scale from 0 (none) to 10 (worst possible) and include feelings of: (1) "dizziness, lightheadedness, feeling faint, or feeling like you might black out"; (2) "Problems with vision (blurring, seeing spots, tunnel vision, etc.)"; (3) "Weakness"; (4) "Fatigue"; (5) "Trouble concentrating"; and (6) "Head and neck discomfort". | Period of work-rest allocations following initial stay time for afternoon day 1 |
| Orthostatic Intolerance Symptoms Assessment | Cumulative sum of scores on 6 questions asking participant to rank symptoms associated with orthostatic intolerance. All symptoms scored on a scale from 0 (none) to 10 (worst possible) and include feelings of: (1) "dizziness, lightheadedness, feeling faint, or feeling like you might black out"; (2) "Problems with vision (blurring, seeing spots, tunnel vision, etc.)"; (3) "Weakness"; (4) "Fatigue"; (5) "Trouble concentrating"; and (6) "Head and neck discomfort". | Period of work-rest allocations following initial stay time for morning day 2 |