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In this functional magnetic resonance imaging study, effects of different information of fat content of high or low fat will be examined in FD patients and healthy volunteers (n=30, respectively). These data will provide a better understanding of symptom generation following food ingestion in general as well as in patients with respective functional gastrointestinal disorders.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Functional dyspepsia patient | Experimental | Yogurt ingestion |
|
| Healthy | Experimental | Yogurt ingestion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Yogurt | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| functional brain activity | Resting BOLD (Blood oxygenation level-dependent) signal before and after yogurt ingestion will compared between groups. There is a small risk of discomfort from claustrophobia, periods of immobility, and exposure to the noise of the magnet. The investigators will offer the participants ear plugs. In rare cases the participants experience dizziness, nausea, or tinnitus which normally disappear after the measurement. During the measurements there is the possibility of warming which could lead to skin irritation in people with tattoos. Therefore, the participants with tattoos will not be included. The participants are instructed to tell the investigators immediately if any uncomforted appears. The study will be performed by experienced experimenters who know all about the risks. During the measurements, the participants are monitored. As a commercial yogurt (200 ml) will be used, the investigators do not expect any side effects. Food allergy will be checked before. | 1-2 years |
| subjective rating | The investigators will measure how much the participants have fullness, satiation, nausea and vomiting, pain, and their mood before and after the yogurt ingestion using visual analog scale. | 1-2 years |
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Inclusion Criteria:
For FD patients, Diagnosis of functional dyspepsia over the last 12 months certified by a medical record Inconspicuous gastroscopy during the last 6 months certified by a medical record
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Paul Enck, Prof. | Psychosomatic Medicine and Psychotherapy Department, University of Tübingen, Tübingen, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Psychosomatic Medicine and Psychotherapy Department, University of Tübingen, Tübingen, Germany | Tübingen | 72072 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29924294 | Derived | Lee IS, Kullmann S, Scheffler K, Preissl H, Enck P. Fat label compared with fat content: gastrointestinal symptoms and brain activity in functional dyspepsia patients and healthy controls. Am J Clin Nutr. 2018 Jul 1;108(1):127-135. doi: 10.1093/ajcn/nqy077. |
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| ID | Term |
|---|---|
| D015014 | Yogurt |
| ID | Term |
|---|---|
| D043302 | Cultured Milk Products |
| D008892 | Milk |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
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| D010829 |
| Physiological Phenomena |
| D000074421 | Fermented Foods |
| D003611 | Dairy Products |
| D005502 | Food |
| D019602 | Food and Beverages |