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A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The time spend with high-intensity (fast) walking is considered to be responsible for the improvements seen, whereas the time spend with low-intensity (slow) walking is considered less important.
This study will assess if IW with maintained fast walking time duration but reduced total time duration (i.e. reduced slow walking time duration) is equally effective as IW with a normal time duration.
Subjects with type 2 diabetes will be included in a crossover, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
After the interventions subjects will undergo a standardized mixed meal tolerance test with assessment of glycemic control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control (CON) | Experimental | No exercise intervention. |
|
| Normal Interval Walking (IW-60). | Experimental | Sixty minutes with repeated cycles of 3 minutes of fast and 3 minutes of slow walking on a treadmill |
|
| Time-reduced Interval Walking (IW-45) | Experimental | Forty-five minutes with repeated cycles of 3 minutes of fast and 1.5 minutes of slow walking on a treadmill |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CON | Behavioral |
| ||
| IW-60 |
| Measure | Description | Time Frame |
|---|---|---|
| Glycemic control | Glycemic control will be assessed after each intervention. Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test. | Within the first 4 hours after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Matsuda insulin sensitivity index | From the measurements of glucose and insulin during the MMTT, the Matsuda index of insulin sensitivity will be assessed. | Within the first 4 hours after the intervention |
| Stumvoll insulin sensitivity index |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Physical Activity Research (CFAS) | Copenhagen | 2100 | Denmark |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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|
| IW-45 | Behavioral |
|
From the measurements of glucose and insulin during the MMTT, the Stumvoll index of insulin sensitivity will be assessed.
| Within the first 4 hours after the intervention |
| Cederholm insulin sensitivity index | From the measurements of glucose and insulin during the MMTT, the Cederholm index of insulin sensitivity will be assessed. | Within the first 4 hours after the intervention |
| HOMA-2 insulin resistance index | From the measurements of glucose and insulin during the MMTT, the HOMA-2 index of insulin resistance will be assessed. | Within the first 4 hours after the intervention |
| D004700 | Endocrine System Diseases |
| D001519 | Behavior |