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A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The reason IW is superior is unknown.
This study will look into whether it is the larger peak intensity during IW or if it is the alternating exercise pattern that is responsible for the larger improvements seen.
Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
After the interventions subjects will undergo a standardized mixed meal tolerance test, with consecutive measurements of blood glucose, insulin and c-peptide.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control (Con) | Experimental | No exercise intervention. |
|
| Interval Walking - 3 min intervals (IW3) | Experimental | One hour of classical interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking. |
|
| Interval Walking - 1 min intervals (IW1) | Experimental | One hour of fast alternating interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control | Behavioral | One hour of rest. |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Glycemic control | Glycemic control will be measured after each intervention. Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test. | Within the first 4 hours after the interventions |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin secretion | Insulin and C-peptide will be measured during the MMTT | Within the first 4 hours after the interventions |
| Insulin sensitivity | From the measurements og glucose and insulin during the MMTT, various indices of insulin sensitivity will be assessed |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kristian Karstoft, MD, PhD | Centre for Physical Activity Research, Rigshospitalet, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Physical Activity Research (CFAS) | Copenhagen | 2100 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27695119 | Derived | Jakobsen I, Solomon TP, Karstoft K. The Acute Effects of Interval-Type Exercise on Glycemic Control in Type 2 Diabetes Subjects: Importance of Interval Length. A Controlled, Counterbalanced, Crossover Study. PLoS One. 2016 Oct 3;11(10):e0163562. doi: 10.1371/journal.pone.0163562. eCollection 2016. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| IW3 | Behavioral | A one hour exercise bout with repeated cycles of 3 min of fast and 3 min of slow walking |
|
|
| IW1 | Behavioral | A one hour exercise bout with repeated cycles of 1 min of fast and 1 min of slow walking |
|
|
| Within the first 4 hours after the interventions |
| D004700 | Endocrine System Diseases |
| D001519 | Behavior |