Dexketoprofen and Etoricoxib in Patients Undergoing Hip Arthroplasty

The Central Nervous Penetration of Dexketoprofen and Etoricoxib and Their Effect on Pain and Inflammatory Reaction in Patients Undergoing Hip Arthroplasty

The main purpose of this study was to determine the plasma and central nervious system pharmacokinetics of dexketoprofen and etoricoxib. The secondary aim was to asses their effect on the concentrations of interleukin 6, prostaglandin E2 and other proinflammatory markers both in plasma and cerebrospinal fluid. Thirdly, the investigators aimed to evaluate their efficacy in postoperative pain treatment.

Inclusion Criteria:

• agreed to participate the study
• American Society of Anesthesiologist s physical status classification 1-3
• elective hip arthroplasty planned
• no contraindications to the study drugs
• no contraindication to lumbar puncture

Exclusion Criteria:

• refused to participate the study
• age less than 40 or over 75 years
• Planned anesthesia method other than spinal anesthesia
• contraindications to the study drugs
• Contraindications to lumbar puncture