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No subjects were recruited
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| Name | Class |
|---|---|
| University of Basel | OTHER |
| Korea University | OTHER |
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The overall goal of the outlined study is to establish a Real-Time (RT) functional Magnetic Resonance Imaging (fMRI) Neurofeedback (NF) (RT-fMRI-NF) protocol aiming at modulating neural, endocrine, and subjective reactivity to psychosocial stress.
The overall goal of the outlined study is to establish an RT-fMRI-NF protocol aiming at modulating neural, endocrine, and subjective reactivity to psychosocial stress. More specifically, the investigators pursue the following goals: a) to evaluate whether neural and subjective stress-reactivity can be modified by training volitional control over targeted brain activity by means of RT-fMRI-NF; b) to evaluate whether neuromodulation by means of RT-fMRI-NF can be used as a new way to modulate hormone-release into the periphery; and c) to evaluate whether the efficacy of neuromodulation by RT-fMRI-NF can also be reflected on EEG data as well as the autonomic nervous system (ANS) measured by heart rate variability (HRV).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Contingent | Experimental | Contingent RT-fMRI-NF |
|
| Non-contingent | Sham Comparator | Sham RT-fMRI-NF |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Contingent RT-fMRI-NF | Other | Subjects are provided with contingent RT-fMRI-NF of brain activity in the target region of interest. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hypothalamic-pituitary-adrenal (HPA) axis reactivity | Assessed via salivary cortisol | At study day one |
| Blood oxygenation level dependent signal of the target brain region of interest | Blood oxygenation level dependent (BOLD) signal assessed via functional magnetic resonance imaging, expressed in relative BOLD signal intensity | At study day one |
| Measure | Description | Time Frame |
|---|---|---|
| Psychophysiological stress reactivity - blood pressure | Assessed via blood pressure | At study day one |
| Psychophysiological stress reactivity - heart rate variability | Assessed via heart rate variability |
| Measure | Description | Time Frame |
|---|---|---|
| Functional connectivity | Connectivity of brain activity determined by fMRI signal | At study day one |
| Feedback on adverse events during the scanner training | Number of subjects reporting an adverse event |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marion Tegethoff, PD Dr. | University of Basel | Principal Investigator |
| Jong-Hwan Lee, Prof. | Korea University | Principal Investigator |
| Gunther Meinlschmidt, Prof. Dr. | University of Basel; Ruhr-University Bochum | Principal Investigator |
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| Sham RT-fMRI-NF | Other | Subjects are provided with sham RT-fMRI-NF of brain activity of previously recorded subject. |
|
| At study day one |
| Psychophysiological stress reactivity - heart rate | Assessed via heart rate | At study day one |
| Subjective stress reactivity | Assessed via Visual Analog Scale | At study day one |
| Electrical activity of the brain | Assessed via electroencephalography (EEG) | At study day one |
| At study day one |