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| Name | Class |
|---|---|
| University of Basel | OTHER |
| Swiss National Science Foundation | OTHER |
| Korea University | OTHER |
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The purpose of this study is to determine the potential efficacy of real-time functional magnetic resonance imaging neurofeedback (RT- functional magnetic resonance imaging (fMRI) -NF) in regulating brain activity and psychophysiological functions.
The overall goal of the outlined study is to establish a real-time functional magnetic resonance imaging neurofeedback (RT-fMRI-NF) protocol aiming at modulating brain activity and psychophysiological functions. About two weeks after the initial training session it will be estimated how stable training effects have been. The two weeks in between, subjects will receive ambulatory training of the strategies via a smartphone-based application.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Contingent | Experimental | Contingent RT-fMRI-NF of brain activity in the target region of interest |
|
| Non-contingent | Sham Comparator | Sham RT-fMRI-NF of brain activity of previously recorded subject |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| real-time functional magnetic resonance imaging neurofeedback (RT-fMRI-NF) | Other | Subjects are provided with RT-fMRI-NF. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure | assessed via oscillometry, expressed in mmHg | study day 1; study day 2 (2 weeks later); anticipated: follow-up (up to 1 year) |
| Blood oxygenation level dependent signal of the target brain region of interest | blood oxygenation level dependent (BOLD) signal assessed via functional magnetic resonance imaging, expressed in relative BOLD signal intensity | study day 1; study day 2 (2 weeks later); anticipated: follow-up (up to 1 year) |
| Measure | Description | Time Frame |
|---|---|---|
| Feedback on adverse events during the scanner and ambulatory training | number of subjects reporting an adverse event | study day 1; study day 2 (2 weeks later); anticipated: follow-up (up to 1 year) |
| Measure | Description | Time Frame |
|---|---|---|
| Psychobiological stress reactivity | assessed via heart rate, cortisol | study day 1; study day 2 (2 weeks later); anticipated: follow-up (up to 1 year) |
| Psychological stress reactivity | assessed via Multidimensional Mood State Questionnaire; Self-Assessment Manikin; Perceived Stress Scale |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marion Tegethoff, PhD | University of Basel | Principal Investigator |
| Jong-Hwan Lee, PhD | Korea University | Principal Investigator |
| Gunther Meinlschmidt, PhD | University of Basel;Ruhr-University Bochum | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Korea University | Seoul | 136-713 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27516747 | Derived | Meinlschmidt G, Lee JH, Stalujanis E, Belardi A, Oh M, Jung EK, Kim HC, Alfano J, Yoo SS, Tegethoff M. Smartphone-Based Psychotherapeutic Micro-Interventions to Improve Mood in a Real-World Setting. Front Psychol. 2016 Jul 28;7:1112. doi: 10.3389/fpsyg.2016.01112. eCollection 2016. |
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| Ambulatory Training | Behavioral | Subjects are provided with an ambulatory training. |
|
| study day 1; study day 2 (2 weeks later); anticipated: follow-up (up to 1 year) |
| Functional connectivity | connectivity of brain activity determined by fmri signal | study day 1; study day 2 (2 weeks later); anticipated: follow-up (up to 1 year) |