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| Name | Class |
|---|---|
| Federal University of Rio Grande do Sul | OTHER |
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This study aims to verify the effects of resistance training on neuromuscular, vascular and functional adaptations of elderly diabetics type 2. Half of participants will be the intervention group that will perform resistance training, while the other half will be the control group that will perform stretching sessions.
Resistance training may be an interesting strategy to fight diabetes deleterious conditions, as it is known to increase muscle mass and quality, strength, functional capacity, vascular health, and decrease inflammation status and blood lipids, besides leading to improves in glycemic control. To test this hypothesis, 42 diabetic patients will be recruited and randomized to two groups that will be evaluated before and after 12 weeks of both intervention or control period. The resistance training group will perform all body resistance exercises three times per week, while the control group will perform a stretching session one time per week.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resistance training | Experimental | Resistance training will be performed three times a week, for 12 weeks, composed by 12 resistance exercises for all body muscles with 2-3 series and 12-8 repetitions in each exercise. |
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| Stretching control | Active Comparator | The control group will perform one stretching session a week. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance training | Other | The resistance training will be compound by 12 exercises for all body muscles, performed three times per week. The intensity of training will be measure by maximum repetitions from 12 until 8 repetitions with 2-3 series. The loads will increase for keep the maximum strength as the capacity of patients. The blood pressure and the casual glycemic will be measure before and after the training in each session. Before to start the exercises, patients will perform a warming on treadmill for 10 minutes and after the training will perform some stretching exercises for muscles groups trained. |
| Measure | Description | Time Frame |
|---|---|---|
| Quadriceps Muscle Quality measure by echo intensity | Echo intensity is a grey scale for analyse the image that ranging from 0 (black) to 255 (white). | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Functional capacity measure by stair climb test. | Total time, as fast as possible, to climb 10 steps. | 12 weeks |
| Quadriceps muscle strength measured by one repetition maximum (1RM) test. | 1RM is a maximum load lifted, reported in kg, during the knee extension. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexandre S Dias, phd | Hospital de Clinicas de Porto Alegre | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital de Clinicas de Porto Alegre | Porto Alegre | Rio Grande do Sul | 90035-903 | Brazil | ||
| Federal University of Rio Grande do Sul, Physical Education School |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Stretching control | Other | The stretching session will be composed by stretching and joint mobilization exercises for all body muscles and will happen only one time per week. |
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| 12 weeks |
| Visceral adipose tissue measured by ultrasonography | Visceral adipose tissue (VAT) thickness measured by ultrasonography. The VAT thickness is considered from the back of the subcutaneous tissue until the anterior part of the aorta. It is reported in mm. | 12 weks |
| Muscle thickness measured by ultrasonography | Muscle thickness measured by ultrasonography takes into account the superior fascia of the muscle and the distance until the inferior fascia. It is reported in mm. | 12 weeks |
| Inflammation status estimated by tumor necrosis factor alpha (TNF-α ) and C reactive protein (CRP) | TNF-α will be evaluated by specific commercial kit and CRP will be measured in a regular laboratorial equipment (COBAS C111). | 12 weeks |
| Lipid profile | HDL, LDL, total cholesterol and triglycerides will be measured in a regular laboratorial equipment (COBAS C111) | 12 weeks |
| Glycemic profile | Blood glycated hemoglobin and glucose will be measured in a regular laboratorial equipment (COBAS C111) | 12 weeks |
| Endothelial function measured by ultrasonography | Endothelial function estimated by the response of endothelial cells for hyperemia. | 12 weeks |
| Quadriceps Muscle Quality measure by specific tension | Specific tension is the ratio between muscle strength and muscle mass. | 12 weeks |
| Functional capacity measure by time up and go test | Time to get up from the chair walk around the marker (3 m) and return to the sitting position, as fast as possible. | 12 weeks |
| Functional capacity measure by sit-to-stand-up test | The time, as fast as possible, to stand and sit on the chair 10 times. | 12 weeks |
| Quadriceps muscle power capacity measure by rate of torque development. | The rate torque development is a slope of torque/time curve. | 12 weeks |
| Porto Alegre |
| Rio Grande do Sul |
| 90690-000 |
| Brazil |
| D004700 | Endocrine System Diseases |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |