Tomography Positron Emission Assessment of the Impact of Cardiac Rehabilitation on Coronary Endothelial Function in Cardiac Failure

In patients with heart failure, the drive to the effort has demonstrated its safety and its interest. Patients with heart failure, endothelium-dependent peripheral vasodilatation is impaired by decreased activity of endothelial NO synthase. The rehabilitation training significantly improves peripheral endothelial function, and this improvement is correlated to the increase in exercise capacity. The impact on coronary endothelial function remains poorly documented, especially in non-ischemic dilated heart disease.

The main objective of this study is to investigate the effectiveness of cardiac rehabilitation on the restoration of coronary endothelial function in cardiac failure patient evaluated with Tomography Positron Emission 15O-H2O.

Inclusion Criteria:

• Patients with heart failure with nonischemic dilated cardiomyopathy
• Class II-III NYHA (New York Heart Association)
• Having no contra-indication to the effort
• Fraction Ejection ≤ 40%
• patient who will have cardiac rehabilitation
• Age over 18 years
• informed consent signed
• patient with a social security scheme

Exclusion Criteria:

• Hypertension> 160/90 mmHg
• High cholesterol level > 6.0 mmol / l
• Diabetes known and treated
• Active smoking
• Valvular heart disease, congenital or ischemic
• Pregnant or breastfeeding women
• Age <18 years
• Major Adult guardianship