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| Name | Class |
|---|---|
| Société Française de Cardiologie | OTHER |
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Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| STEMI | Other | All patients included in this study (1 arm) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| (15)-O water positron emission tomography and Biomarkers | Other | Coronary endothelial function is assessed using (15)-O water positron emission tomography and cold pressor test . The response to the test is defined by the percentage increase myocardial blood flow . Assessment of fibrosis, inflammation an endothelial function is performed using biomarkers. |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of coronary endothelial function | 3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) . | 3 months |
| Measurement of fibrosis | 3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) . | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Correlating biomarkers with local and global parameters of coronary endothelial function , inflammation and myocardial fibrosis with early echocardiographic parameters of left ventricular remodeling and cardiac magnetic resonance imaging | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Farzin GF BEYGUI, PhD | University Hospital, Caen | Study Chair |
| Alain MA Manrique, PhD | University Hospital, Caen | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHu de Caen | Caen | Normandy | 14000 | France |
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|
| ID | Term |
|---|---|
| D000072657 | ST Elevation Myocardial Infarction |
| D020257 | Ventricular Remodeling |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D020763 | Pathological Conditions, Anatomical |
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| ID | Term |
|---|---|
| D015415 | Biomarkers |
| ID | Term |
|---|---|
| D001685 | Biological Factors |
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