Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction

Assessment of Coronary Endothelial Function and Myocardial Fibrosis in Positron Emission Tomography With the Waning of Acute Coronary Syndrome With Elevated ST Segment : Relationship With Left Ventricular Remodeling

Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.

Inclusion Criteria:

• First ST Elevation Myocardial Infarction
• Primary Percutaneous Coronary Intervention (TIMI 3)
• Single vessel coronary artery disease
• Age over 18 years
• Informed Consent dated and signed
• Written and spoken French
• Beneficiary of social security insurance

Exclusion Criteria:

• No Primary Percutaneous Coronary Intervention
• TIMI 0-2 after Primary Percutaneous Coronary Intervention
• Significant two or three-vessel coronary artery disease (> 70% stenosis in at least one of the other two coronary arteries)
• Past history of myocardial infarction before STEMI
• Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure
• Pregnant and / or lactating
• Age under 18 years or guardianship