Myocardial Blood Flow by 15O Water PET

Validation of Computed Tomography Myocardial Perfusion Imaging Using Quantification of Myocardial Blood Flow by Positron Emission Tomography With 15O-water

Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease. In this study the investigators plan to investigate a special scan called a PET/CT (Positron emission tomography/computed tomography) and a new type of CT (Computed tomography) scan to tell us about the flow of blood to the heart muscle.

Participants will undergo PET/CT with oxygen-15 labelled water and computed tomography myocardial perfusion imaging.

Inclusion Criteria:

• suspected coronary artery disease

Exclusion Criteria:

• inability or unwillingness to undergo CT or PET imaging
• renal failure (serum creatinine >200 um/L or eGFR <30 ml/min)
• hepatic failure
• allergy to iodinated contrast
• pregnancy
• contraindication to adenosine
• inability to give informed consent
• atrial fibrillation with a fast ventricular rate (>70 beats per minute)