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The trial will include 75 patients with evident or suspected ischemic heart disease refered to Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, for perfusion imaging by 15O-H2O PET/CT scan of the heart during rest and stress. Instead of the clinical scan participants will undergo perfusion imaging by 15O-H2O PET/MR.
The clinician will receive diagnostic information based on the 15O-H2O PET scan as if the patient had not participated in the study. As such, the study has no influence on the diagnostics or treatments of the patient.
Data from the scans will be used to compare 15O-H2O PET with cardiac MR for evaluation of myocardial perfusion.
Follow up will be done for up to 10 years in regards to major cardiovascular events in order to determine the prognostic value of the scan.
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| Measure | Description | Time Frame |
|---|---|---|
| Difference in myocardial blood flow | The difference in assessed myocardial blood flow as measured by 15O-H2O PET and MR | 2 years |
| Prognostic value within 10 years | Number of participants who experience a major adverse cardiac event within 10 years of follow-up. | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in coronary flow reserve | The difference in assessed myocardial blood flow as measured by 15O-H2O PET and MR | 2 Years |
| Difference in predictive value | The difference in predictive value of myocardial blood flow measurements as measured by 15O-H2O PET and MR |
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Inclusion Criteria:
Exclusion Criteria:
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Any patient with known or suspected ischemic heart disease referred for a clinical H2O-PET at Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, not meeting any exclusion criteria will be enrolled in the study.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aarhus University Hospital | Aarhus | Aarhus N | 8200 | Denmark |
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| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D003327 | Coronary Disease |
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| 10 years |
| Difference in left ventricular end-systolic volume | The difference in left ventricular end-systolic volume as measured by 15O-H2O PET and MR | 2 years |
| Difference in left ventricular end-diastolic volume | The difference in left ventricular end-diastolic volume as measured by 15O-H2O PET and MR | 2 years |
| Difference in right ventricular end-systolic volume | The difference in right ventricular end-systolic volume as measured by 15O-H2O PET and MR | 2 years |
| Difference in right ventricular end-diastolic volume | The difference in right ventricular end-diastolic volume as measured by 15O-H2O PET and MR | 2 years |
| Difference in left ventricular mass | The difference in left ventricular mass as measured by 15O-H2O PET and MR | 2 years |
| Amount of scar tissue | Scar tissue assessment as measured by MR | 2 years |
| Pulmonary transit time | Pulmonary transit time as measured by 15O-H2O PET | 2 years |
| Pulmonary perfusion | Pulmonary perfusion as measured by 15O-H2O PET | 2 years |
| Prognostic value within 3,5 years | Number of participants who experience a major adverse cardiac event within 3,5 years of follow-up. | 5 years |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |