Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects

Recently, we have shown functional resonance imaging (fMRI) that variations in signal induced by a language task were significantly lower in a semantic region of the left hemisphere (comprised of that part pars triangularis of the inferior frontal gyrus and the temporal gyri medium and angular) in schizophrenic patients compared with controls matched for age, sex, level of education and handedness.

Investigators wish to test the hypothesis that functional modification of the hemispherical specialization is specific language and also specific for schizophrenia.

Inclusion Criteria:

• patients under 65 years
• Schizophrenics, bipolar or schizoaffective (DSM IV)
• Patients who signed informed consent

Exclusion Criteria:

• Women with childbearing potential without effective contraception or positive pregnancy test.
• Contra-indications to fMRI