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| ID | Type | Description | Link |
|---|---|---|---|
| HAO 2013 | Other Grant/Funding Number | Maison des sciences de l'homme de Toulouse |
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For bilingual and multilingual patients, brain activation and Electric Stimulation Mapping studies have shown that different languages may be localized, at least partially, in distinct microanatomical systems located within the same gross anatomical areas.
The present investigation involves both types of healthy bilinguals with carefully controlled proficiency levels, as well as bilingual patients suffering from low-grade glioma.
Functional magnetic resonance imaging data will be collected while the participants perform a picture naming task in blocked conditions for both languages (either English or French) or in switch condition (English and French). A stimulation mapping study will be conducted in the patients during awake surgery with the same tasks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy early bilinguals | Experimental | healthy early bilinguals functional magnetic resonance imaging |
|
| healthy late bilinguals | Experimental | healthy late bilinguals functional magnetic resonance imaging |
|
| bilingual patients | Experimental | bilingual patients suffering from low-grade glioma in the language areas functional magnetic resonance imaging |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| functional magnetic resonance imaging | Device | Stimuli will be presented in 3 language conditions, French, English and "switch" in which the participant alternates between English and French every trial. A block design will be used, with 7 line drawings per language condition. Four 9-minute runs will be performed, there being 2 action runs and 2 object runs. In each run, there are 6 blocks of each language condition, presented in a fixed random order. No drawings are repeated. Each stimulus is preceded either by an English or a French prompt word ("to" or "faire" for actions and, "say" or "dire" for objects) for 450 msec; stimuli are presented for 1.5 seconds and followed by a blank screen for 1 second. Language blocks are separated by a variable duration (from 8 to 10 seconds). |
| Measure | Description | Time Frame |
|---|---|---|
| Brain activity | The primary judgment criteria is brain activity as measured by functional magnetic resonance imaging :
| 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Brain activity | The secondary judgment criteria is brain activity measured by functional magnetic resonance imaging :
| 24 hours |
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Inclusion Criteria:
Patients:
Healthy volunteers:
Exclusion Criteria:
Patients:
Healthy volunteers:
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| Name | Affiliation | Role |
|---|---|---|
| Vincent LUBRANO, MD, PhD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Toulouse | Toulouse | 31059 | France |
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| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
| D001927 |
| Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |