The Impact of the SCN9A Gene Polymorphism on Postoperative Pain

The Impact of the Single Nucleotide Polymorphisms rs6746030,rs7604448, rs10930214, s7595255 in SCN9A Gene on Postoperative Pain and Analgesic Consumption After Cesarean Section

The purpose of this study to determine the association between postoperative pain after cesarean section and several single nucleotide polymorphisms in SCN9A sodium channels gene.

SCN9A gene encodes an alpha subunit of the voltage-gated sodium channel (Nav1.7) and polymorphisms of this gene are associated with severe pain disorders. The impact of the polymorphisms in SCN9A on postoperative pain and opioid consumption after cesarean section is unclear.

Inclusion Criteria:

• The women aged 18 to 45,
• in 36 to 40 weeks of pregnancy
• undergoing cesarean section

Exclusion Criteria:

• History of chronic pain or pain disorders
• Psychiatric diseases
• Diabetes mellitus
• Severe cardiovascular, kidney or liver diseases
• Alcohol or drug abuse
• Heavy smoker
• Unable to use the Patient controlled analgesia (PCA) pump