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| Name | Class |
|---|---|
| IMS Health | OTHER |
| OXON Epidemiology | INDUSTRY |
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The purpose of this study is to determine and compare the persistence rate of newly prescribed apixaban, rivaroxaban, dabigatran and VKAs in patients with NVAF.
Actual number of patients enrolled for UK : 15242 patients
Actual number of patients enrolled for Germany : 22880 patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient treated with Apixaban | |||
| Patient treated with Rivaroxaban | |||
| Patient treated with Dabigatran | |||
| Patient treated with vitamin K antagonists |
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| Measure | Description | Time Frame |
|---|---|---|
| Persistence rate of newly prescribed apixaban, rivaroxaban, dabigatran and vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation(NVAF) | We defined non-persistence in the databases as the absence of index prescription for twice the median prescription duration; and calculated cumulative incidence (95% CIs) of persistence at the end of follow-up and at different time points after treatment initiation (3, 6, and 12 months) | 23 months for the UK and Germany, 25 months for France |
| Measure | Description | Time Frame |
|---|---|---|
| Demographic characteristics (Age, Gender, Smoking status, region of practice, data source) of patients with newly prescribed oral anticoagulants | 23 months for the UK and Germany, 25 months for France | |
| Clinical characteristics (History of bleeding, myocardial infarction, stroke, Thromboembolism, congestive heart failure, vascular disease, hypertension, CHA2DS2-VASc score, HAS-BLED score, etc) of patients with newly prescribed oral anticoagulants |
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Inclusion Criteria:
Exclusion Criteria:
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Primary Care Clinic
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| Name | Affiliation | Role |
|---|---|---|
| Bristol-Myers Squibb | Bristol-Myers Squibb | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29398546 | Derived | Collings SL, Vannier-Moreau V, Johnson ME, Stynes G, Lefevre C, Maguire A, Asmar J, Bizouard G, Duhot D, Mouquet F, Fauchier L. Initiation and continuation of oral anticoagulant prescriptions for stroke prevention in non-valvular atrial fibrillation: A cohort study in primary care in France. Arch Cardiovasc Dis. 2018 May;111(5):370-379. doi: 10.1016/j.acvd.2017.10.003. Epub 2018 Feb 3. | |
| 27678530 |
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| 23 months for the UK and Germany, 25 months for France |
| Adherence to newly prescribed oral anticoagulants based on Medication possession ratio (MPR) | 23 months for the UK and Germany |
| Compare persistence rates across oral anticoagulant therapies | 23 months for the UK and Germany, 25 months for France |
| Derived |
| Johnson ME, Lefevre C, Collings SL, Evans D, Kloss S, Ridha E, Maguire A. Early real-world evidence of persistence on oral anticoagulants for stroke prevention in non-valvular atrial fibrillation: a cohort study in UK primary care. BMJ Open. 2016 Sep 26;6(9):e011471. doi: 10.1136/bmjopen-2016-011471. |