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| Name | Class |
|---|---|
| National Basic Research Program, China | OTHER |
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The purpose of this study is to clarify whether distal-proximal point association is more effective than partial match point association by electro-acupuncture in the management of chemotherapy-induced nausea and vomiting .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| only antiemetic | Active Comparator | The participants in the control group received standard antiemetic alone. Standard antiemetic for all groups is based on American Society of Clinical Oncology cClinical pPractice gGuideline. The 5-hydroxytryptamine-3 (5-HT3) antagonist (Ramosetron, Tropisetron) and dexamethasone are administered before the chemotherapy treatment. |
|
| Matching points ST36+CV12 | Experimental |
| |
| Matching points PC6+CV12 | Experimental |
| |
| Matching points CV3+CV12 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| only antiemetic (Ramosetron, Tropisetron and dexamethasone) | Drug | The control group will receive standard antiemetic alone. Standard antiemetic for all groups is based on American Society of Clinical Oncology clinical practice guideline. 5-hydroxytryptamine-3 (5-HT3) antagonist (Ramosetron, Tropisetron) and dexamethasone are supplied from the first day of chemotherapy, and lasting for 3-5 days.And plus antiemetic drug as the comparator group. |
| Measure | Description | Time Frame |
|---|---|---|
| the frequency of Nausea and Vomiting | 3 weeks | |
| the extent of Nausea and Vomiting | 3 weeks | |
| Rhodes Index of Nausea, Vomiting and Retching | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| the condition of constipation and diarrhea | 3 weeks | |
| gastric electrical activity (electrogastrogram) | 3 weeks | |
| the life quality of the patients |
| Measure | Description | Time Frame |
|---|---|---|
| the number of blood cells | the number of WBC,RBC,hemoglobin,PLT,the percents of GRA,LYM | 3 weeks |
| cardial electrical activity | 3 weeks | |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin University of TCM | Tianjin | Tianjin Municipality | 300193 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27821107 | Derived | Gao L, Chen B, Zhang Q, Zhao T, Li B, Sha T, Zou J, Guo Y, Pan X, Guo Y. Acupuncture with different acupoint combinations for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial. BMC Complement Altern Med. 2016 Nov 8;16(1):441. doi: 10.1186/s12906-016-1425-1. |
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|
| Matching points ST36+CV12 plus antiemetic drug | Other | Choose both Zusanli(ST36) and Zhongwan point(CV12). Manipulating until achieving a "de Qi" sensation, then the needles are connected through a electro-acupuncture apparatus, the positive poles are linked to the needle, and the reference poles are located near the acupoint about 1cm with a paster. Frequency 10Hz,the intensity of stimulation is adjusted according to the patient's tolerance, and the electric current is less than 10mA. The operation lasts for 30 min. The treatment is scheduled to occur within 30min-60min before chemotherapy infusion for 4 days.And plus antiemetic drug as the comparator group. |
|
| Matching points PC6+CV12 plus antiemetic drug | Other | Choose both Neiguan(PC6) and Zhongwan point(CV12). Manipulating until achieving a "de Qi" sensation, then the needles are connected through a electro-acupuncture apparatus, the positive poles are linked to the needle, and the reference poles are located near the acupoint about 1cm with a paster. Frequency 10Hz,the intensity of stimulation is adjusted according to the patient's tolerance, and the electric current is less than 10mA. The operation lasts for 30 min. The treatment is scheduled to occur within 30min-60min before chemotherapy infusion for 4 days.And plus antiemetic drug as the comparator group. |
|
| Matching points CV13+CV12 plus antiemetic drug | Other | Choose both Shangwan(CV13) and Zhongwan point(CV12). Manipulating until achieving a "de Qi" sensation, then the needles are connected through a electro-acupuncture apparatus, the positive poles are linked to the needle, and the reference poles are located near the acupoint about 1cm with a paster. Frequency 10Hz,the intensity of stimulation is adjusted according to the patient's tolerance, and the electric current is less than 10mA. The operation lasts for 30 min. The treatment is scheduled to occur within 30min-60min before chemotherapy infusion for 4 days.And plus antiemetic drug as the comparator group. |
|
| 3 weeks |
| the Anxiety and Depression of the patients | 3 weeks |
| hepatic function |
The Outcome Measures will be assessed by blood, the metrics of ALT,AST,TBIL is IU/L,IU/L,and μmol/L. |
| 3 weeks |
| other adverse effect during the chemotherapy | 3 weeks |
| renal function | The Outcome Measures will be assessed by blood, the metrics of BUN,Scr is mmol/L and μmol/L. | 3 weeks |
| ID | Term |
|---|---|
| D014839 | Vomiting |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C071315 | ramosetron |
| D000077526 | Tropisetron |
| D003907 | Dexamethasone |
| D000932 | Antiemetics |
| ID | Term |
|---|---|
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D001337 | Autonomic Agents |
| D018373 | Peripheral Nervous System Agents |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |
| D005765 | Gastrointestinal Agents |
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