The Effect and Mechanism of Electroacupuncture on Acute Chemotherapy-induced Nausea and Vomiting

The purpose of this study is to compare the preventive effect of electroacupuncture and sham acupuncture on acute chemotherapy-induced nausea and vomiting and then investigate its potential mechanism by using functional Magnetic Resonance Imaging (fMRI).

Inclusion Criteria:

• First diagnosed stage Ⅲ-Ⅳ lung cancer patients on cisplatin chemotherapy;
• Right-handed and aged 18 to 75 years;
• Karnosky performance status (KPS) ≥ 70;
• Life expectancy ≥ 6 months.

Exclusion Criteria:

• Had brain metastases or other concurrent life-threatening diseases;
• Nausea and/or vomiting were present 24h before chemotherapy treatment;
• Suffered from or had a history of gastrointestinal diseases;
• Had a history of head trauma, serious neurological or psychiatric disorders;
• Participating in other clinical trials currently;
• Had any contraindication to exposure to a high magnetic field or receive acupuncture