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| Name | Class |
|---|---|
| National Basic Research Program, China | OTHER |
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The purpose of this study is to clarify whether the matching acupoints are more effective than a single point by electro-acupuncture in the management of chemotherapy-induced nausea and vomiting .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single point PC6 | Experimental | choose single point: Neiguan(PC6).Neiguan(PC6): On the anterior aspect of the forearm,between the tendons of the palmaris longus and the flexor carpi radialis, 2 B-cun proximal to the palmar wrist crease.Manipulating until achieving a "de Qi" sensation, then the needle is connected through a electro-acupuncture apparatus,the positive pole is linked to the needle, and the reference pole is located near the acupoint about 1cm with a paster. Frequency 10Hz,the intensity of stimulation is adjusted according to the patient's tolerance, and the electric current is less than 10mA. The operation lasts for 30 min. The treatment is scheduled to occur within 30min-60min before chemotherapy infusion for 4 days. |
|
| Single point CV12 | Experimental | choose another single point Zhongwan(CV12). Zhongwan(CV12): On the upper abdomen, 4 B-cun superior to the centre of the umbilicus, on the anterior median line. Manipulating until achieving a "de Qi" sensation, then the needle is connected through a electro-acupuncture apparatus,the positive pole is linked to the needle, and the reference pole is located near the acupoint about 1cm with a paster. Frequency 10Hz,the intensity of stimulation is adjusted according to the patient's tolerance, and the electric current is less than 10mA.The operation lasts for 30 min. The treatment is scheduled to occur within 30min-60min before chemotherapy infusion for 4 days. |
|
| Matching points PC6+CV12 | Experimental | Choose both Neiguan point(PC6) and Zhongwan point(CV12). Manipulating until achieving a "de Qi" sensation, then the needles are connected through a electro-acupuncture apparatus, the positive poles are linked to the needle, and the reference poles are located near the acupoint about 1cm with a paster. Frequency 10Hz,the intensity of stimulation is adjusted according to the patient's tolerance, and the electric current is less than 10mA. The operation lasts for 30 min. The treatment is scheduled to occur within 30min-60min before chemotherapy infusion for 4 days. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| single point Neiguan(PC6) plus antiemetic drug | Other |
| ||
| single point Zhongwan(CV12) plus antiemetic drug |
| Measure | Description | Time Frame |
|---|---|---|
| the frequency of Nausea and Vomiting | 6days |
| Measure | Description | Time Frame |
|---|---|---|
| the grading of constipation and diarrhea | 3 weeks | |
| electrogastrogram | 3 weeks | |
| the assessment of quality of life |
| Measure | Description | Time Frame |
|---|---|---|
| blood routine examination | 3 weeks | |
| electrocardiogram | 3 weeks | |
| hepatic and renal function |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin University of TCM | Tianjin | Tianjin Municipality | 300193 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25963295 | Derived | Chen B, Hu SX, Liu BH, Zhao TY, Li B, Liu Y, Li MY, Pan XF, Guo YM, Chen ZL, Guo Y. Efficacy and safety of electroacupuncture with different acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial. Trials. 2015 May 12;16:212. doi: 10.1186/s13063-015-0734-x. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jan 12, 2021 | |
| Reset | Feb 1, 2021 |
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| only antiemetic | Active Comparator | The control group will receive standard antiemetic alone. Standard antiemetic for all groups is based on American Society of Clinical Oncology clinical practice guideline. 5-hydroxytryptamine-3 (5-HT3) antagonist (Ramosetron, Tropisetron) and dexamethasone are supplied from the first day of chemotherapy, and lasting for 3-5 days. |
|
| Other |
|
| matching points Neiguan(PC6) and Zhongwan(CV12) plus antiemetic drug | Other |
|
| only antiemetic drug | Drug |
|
| 3 weeks |
| the assessment of Anxiety and Depression | 3 weeks |
| 3 weeks |
| other adverse effect during the chemotherapy | 3 weeks |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jan 12, 2021 | Feb 1, 2021 |
| ID | Term |
|---|---|
| D014839 | Vomiting |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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