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Intervention studies do not account for high within-individual variation potentially compromising the magnitude of an effect. Repeat administration of a treatment allows quantification of individual responses and determination of the consistency of responses. The investigators aim to determine the consistency of metabolic and exercise responses following repeated administration of sodium bicarbonate (SB). Design and Methods: 15 physically active males will complete six cycling capacity tests at 110% of maximum power output (CCT110%) following ingestion of either 0.3 g∙kg-1Body Mass of SB (4 trials) or placebo (PL, 2 trials). Blood pH, bicarbonate, base excess and lactate will be determined at baseline, pre-exercise, post-exercise and 5-min post-exercise. Total work done (TWD) will be recorded as the exercise outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | 0.3 g∙kg-1body mass of calcium carbonate |
|
| Sodium bicarbonate | Experimental | 0.3 g∙kg-1body mass of sodium bicarbonate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sodium bicarbonate | Dietary Supplement |
| ||
| calcium carbonate |
| Measure | Description | Time Frame |
|---|---|---|
| blood pH | 5 min after a physical exercise test |
| Measure | Description | Time Frame |
|---|---|---|
| blood bicarbonate | 5 min after a physical exercise test | |
| blood lactate | 5 min after a physical exercise test | |
| anaerobic exercise capacity |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Sao Paulo | São Paulo | São Paulo | 05508-30 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26574755 | Derived | Froio de Araujo Dias G, da Eira Silva V, de Salles Painelli V, Sale C, Giannini Artioli G, Gualano B, Saunders B. (In)Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study. PLoS One. 2015 Nov 17;10(11):e0143086. doi: 10.1371/journal.pone.0143086. eCollection 2015. |
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| ID | Term |
|---|---|
| D017693 | Sodium Bicarbonate |
| D002119 | Calcium Carbonate |
| ID | Term |
|---|---|
| D001639 | Bicarbonates |
| D002254 | Carbonates |
| D002255 | Carbonic Acid |
| D017554 | Carbon Compounds, Inorganic |
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| Dietary Supplement |
|
as assessed by cycling capacity tests at 110% of maximum power output |
| 4 hours after supplementation |
| D007287 |
| Inorganic Chemicals |
| D017670 | Sodium Compounds |
| D017610 | Calcium Compounds |
| D008903 | Minerals |