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| Name | Class |
|---|---|
| GlaxoSmithKline | INDUSTRY |
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Regular consumption of fruits and vegetables may improve human health and reduce the risk of chronic diseases, such as heart disease, certain cancers and type 2 diabetes, but the active components and the underlying mechanisms are poorly understood. Berry fruits are abundant in anthocyanins and this study aims to test the hypothesis that ingestion of an anthocyanin-rich blackcurrant beverage will improve markers of cardiovascular health (health of blood vessels, inflammation and platelet function). Further, the study will investigate the anthocyanin bioavailability from the blackcurrant beverage.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Active Comparator | Spray dried blackcurrant powder dissolved in water |
|
| Placebo | Placebo Comparator | (sucrose, glucose, fructose, maltodextrin, malic acid, citric acid, vitamin C, artificial blackcurrant flavouring and low-nitrate water) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beverage: Spray dried blackcurrant powder dissolved in water | Other |
| ||
| Beverage: Placebo (sucrose, glucose, fructose, maltodextrin, malic acid, citric acid, vitamin C, artificial blackcurrant flavouring and low-nitrate water) |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in vascular reactivity measured by flow-mediated dilatation (FMD) | Acute study: measured at baseline and 1, 2, 4 and 6 h post intervention | |
| Change from baseline in platelet function measured by agonist-induced platelet aggregation | Acute study: measured at baseline and 2 and 4 h post intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in the concentration of polyphenols and their metabolites and degradants in blood and urine samples measured by HPLC-MS/MS | Acute study: plasma measured at baseline and 1, 2, 4, 6 and 24 h post intervention, urine measured at baseline and 1, 2, 4, 6 and 6-24 h post intervention | |
| Change from baseline in vascular function measured by digital volume pulse (DVP) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Parveen Yaqoob, DPhil | University of Reading | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Reading | Reading | RG6 6AP | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40414296 | Derived | Amini AM, Zhou R, Austermann K, Kralova D, Serra G, Ibrahim IS, Corona G, Bergillos-Meca T, Aboufarrag H, Kroon PA, Spencer JP, Yaqoob P. Acute Effects of an Anthocyanin-Rich Blackcurrant Beverage on Markers of Cardiovascular Disease Risk in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. J Nutr. 2025 Jul;155(7):2275-2289. doi: 10.1016/j.tjnut.2025.05.017. Epub 2025 May 23. |
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| Other |
|
| Acute study: measured at baseline and 2, 4 and 6 h post intervention |
| Change from baseline in blood pressure | Acute study: measured at baseline and 1, 2, 4 and 6 h post intervention |
| Change from baseline in the concentration of nitric oxide in plasma measured by ozone-based chemiluminescence | Acute study: measured at baseline and 1, 2, 4 and 6 h post intervention |
| Change from baseline in the concentration of selected cytokines (TNF-a, IL-1b, IL-6, IL-8 and IL-10) in plasma measured using a cytometric bead array kit from BD Biosciences | Acute study: measured at baseline and 1, 2, 4 and 6 h post intervention |
| Change from baseline in platelet function (numbers of circulating micro particles by nano particle tracking analysis) | Acute study: measured at baseline and 1, 2, 4 and 6 h post intervention (urine metabonomics additionally 6-24h) |
| Metabonomics on urine and plasma samples measured by nuclear magnetic resonance spectroscopy | Acute study: measured at baseline and 1, 2, 4 and 6 h post intervention (urine metabonomics additionally 6-24h) |
| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D014867 | Water |
| D013395 | Sucrose |
| D005947 | Glucose |
| D005632 | Fructose |
| C008315 | maltodextrin |
| C030298 | malic acid |
| D019343 | Citric Acid |
| D001205 | Ascorbic Acid |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
| D004187 | Disaccharides |
| D009844 | Oligosaccharides |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D000073893 | Sugars |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D007661 | Ketoses |
| D002951 | Citrates |
| D014233 | Tricarboxylic Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D013400 | Sugar Acids |
| D006880 | Hydroxy Acids |
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