Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This is a prospective biobank set up to collect serum from patients with disorders associated with changes in androgens, estrogens or sex hormone-binding globulin (SHBG), before and/or after treatment.
In vitro cell-based bioassays may be a technique to measure serum androgen or estrogen bioactivity. In this study investigators are collecting serum (and if possible, urine) samples from different cohorts of patients, before and/or after treatment.
The aim is to measure androgens, estrogens and SHBG as well as in vitro bioactivity with newly developed cell-based bioassays, and to compare different techniques to each other as well as to clinical endpoints available in the patient's Electronic Health Record.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Medical castration | Patients treated with androgen deprivation therapy (e.g. for hypersexuality, transgender subjects, ...) |
| |
| Male hypogonadism | Patients treated with testosterone replacement therapy (e.g. for late-onset hypogonadism, secondary hypogonadism) |
| |
| Thyroid disorders | Patients treated for hyperthyroidism or hypothyroidism (incl. during treatment for thyroid cancer) |
| |
| Obesity and weight loss | Patients treated for obesity with weight loss interventions (mainly bariatric surgery) |
| |
| Miscellaneous | Various disorders associated with alterations in SHBG, androgens and/or estrogens |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Serum (with or without urine) samples | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Testosterone bioequivalents (in nanomolar) | second blood sample at time of clinical follow-up (between 3 weeks and 1 year interval) | |
| Estradiol bioequivalents (in picomolar) | second blood sample at time of clinical follow-up (between 3 weeks and 1 year interval) |
| Measure | Description | Time Frame |
|---|---|---|
| Calculated free and bioavailable testosterone (in nanomolar) | second blood sample at time of clinical follow-up (between 3 weeks and 1 year interval) | |
| Calculated free and bioavailable estradiol (in picomolar) | second blood sample at time of clinical follow-up (between 3 weeks and 1 year interval) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Patients in the department of Endocrinology/Andrology, Urology and Oncology
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Dirk Vanderschueren, MD, PhD | UZ Leuven | Principal Investigator |
Not provided
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27576188 | Result | Laurent MR, Helsen C, Antonio L, Schollaert D, Joniau S, Vos MJ, Decallonne B, Hammond GL, Vanderschueren D, Claessens F. Effects of sex hormone-binding globulin (SHBG) on androgen bioactivity in vitro. Mol Cell Endocrinol. 2016 Dec 5;437:280-291. doi: 10.1016/j.mce.2016.08.041. Epub 2016 Aug 26. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D007006 | Hypogonadism |
| ID | Term |
|---|---|
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Serum and urine
| Total serum testosterone (in nanomolar) | Measured by immunoassay or liquid chromatography tandem mass spectrometry (LC-MS/MS) | second blood sample at time of clinical follow-up (between 3 weeks and 1 year interval) |
| Total serum estradiol (in picomolar) | Measured by immunoassay or LC-MS/MS | second blood sample at time of clinical follow-up (between 3 weeks and 1 year interval) |
| Total serum SHBG (in nanomolar) | Measured by immunoassay | second blood sample at time of clinical follow-up (between 3 weeks and 1 year interval) |