Effects of Replacement Therapy With Sexual Steroid Hormones on the Insulin Sensitivity of Hypogonadal Man

Sexual steroids administered to supra-physiological doses are likely to change the carbohydrate and lipid metabolism.

Investigators propose to study in 12 hypogonadal men hypogonadotropic or hypergonadotropic treated with aromatase inhibitor, the respective effects of estradiol, testosterone or both steroids administered in a cross-over Latin squares plan on insulin sensitivity measured by the reference method of the hyperinsulinemic euglycemic clamp.

Inclusion Criteria:

• Hypogonadism hypogonadotropic or hypergonadotropic
• Man aged 18-60 years
• BMI between 18 and 27.

Exclusion Criteria:

• Other ante-pituitary deficiency
• Chronic treatment modifying carbohydrate metabolism (thiazides, beta 2 mimetics, steroids ...)
• Diabetes
• Obesity diffuse or android
• Hemochromatosis
• osteoporosis
• chronic diseases
• neoplasia
• High blood pressure