Healing of Persistent Epithelial Defects

Comparison of Standard of Care Treatments for Post-operative Non-healing Epithelial Defects

The purpose of this study is to compare the relative efficacy of four different treatment modalities (i.e. aggressive lubrication, bandage contact lens, Ambiodisk amniotic membrane, Prokera amniotic membrane) in the healing of persistent corneal epithelial defects following retina surgery.

3.1 Inclusion Criteria

• Adults aged 18 and older (inclusive) at the time of study enrollment
• Recent history of retina surgery
• Presence of persistent epithelial defect 7 days or later after surgery
• English speaking

3.2 Exclusion Criteria

• Non-English speaking patients
• Inability to incapacity to provide consent for the study
• History of corneal epithelial or limbal stem cell disease