Treatment of PED With AMT and Autologous Serum

Efficacy of Amniotic Membrane Transplantation and Autologous Serum in Treatment of Persistent Epithelial Defects

Patients with persistent corneal epithelial defects who have not responded to conventional therapy will be randomized to treatment with either amniotic membrane transplantation or autologous serum 20%. Outcome measures will be (1) presence or absence of complete re-epithelialization within 28 days and (2) retention of intact epithelium for at least 90 days.

Inclusion Criteria:

• Corneal epithelial defect of more than 14 days that has not responded to conventional therapy

Exclusion Criteria:

• Under age 18
• Pregnant/lactating females
• Patients with hemoglobin levels < 12 mg/ml
• Patients with limbal stem cell deficiency