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There is some evidence to suggest that ginseng and Ginkgo biloba can improve cognitive performance, however, very little is known about the mechanisms associated with such improvement. Here, we tested whether cardiovascular reactivity to a task is associated with cognitive improvement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Experimental | Study subjects received, in a double blind fashion, placebo pills identical to the drug (ginseng: group 1; ginkgo biloba: group 2). |
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| Ginseng | Experimental | Participants in the ginseng group received a medium, and higher dose of ginseng in addition to placebo capsules. |
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| Ginkgo Biloba | Experimental | Participants in the ginkgo biloba group received a medium, and higher dose of ginkgo in addition to placebo capsules. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Drug | Study subjects received, in a double blind fashion, placebo pills identical to the drug (drug 1-ginseng, group 1; drug 2-ginkgo biloba-group 2) |
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| Measure | Description | Time Frame |
|---|---|---|
| Cognitive performance as modulated by either ginseng or ginkgo biloba | Cognitive effects on tests of vigilance/attention, behavioural flexibility and executive functioning | Acute effects (3 days of testing) |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular reactivity as a result of ginseng or ginkgo biloba intake | Changes in systolic, diastolic and heart rate reading as a result of ginseng or ginkgo biloba intake and dependent upon the type of cognitive domain assessed (i.e. vigilance, behavioural flexibility or executive functioning. | Acute effects (3 days of testing) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luca Aquili, PhD | Sunway University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychology, Sunway University | Sunway City | Selangor | 47500 | Malaysia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26938637 | Derived | Ong Lai Teik D, Lee XS, Lim CJ, Low CM, Muslima M, Aquili L. Ginseng and Ginkgo Biloba Effects on Cognition as Modulated by Cardiovascular Reactivity: A Randomised Trial. PLoS One. 2016 Mar 3;11(3):e0150447. doi: 10.1371/journal.pone.0150447. eCollection 2016. |
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| ID | Term |
|---|---|
| C000713447 | Asian ginseng |
| D000096983 | Ginkgo Extract |
| ID | Term |
|---|---|
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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| Ginseng | Drug | The ginseng group received two capsules containing either 1000 mg or 500 mg of Panax Ginseng extract standardized to 3% of ginsenosides (GNC, USA) or similarly looking placebo capsules over a period of three days of testing. |
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| Ginkgo Biloba | Drug | The ginkgo group received two capsules containing either 240 mg or 120 mg of ginkgo biloba extract standardized to 24% ginkgo flavone glycosides and 6% terpene lactones (GBE24/6) or similarly looking placebo capsules over a period of three testing days. |
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