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The purpose of this study is to determine the effectiveness of recommending either a Paleolithic based diet or the United States Department of Agriculture MyPlate guidelines with or without exercise on physical conditioning, hormones related to energy metabolism, body composition, resting energy expenditure, blood biomarkers, and urine in young, adult females.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MyPlate | Active Comparator | To consume a weight maintenance diet based on the United States Department of Agriculture MyPlate nutrition recommendations for eight weeks. |
|
| MyPlate + Exercise | Active Comparator | To consume a weight maintenance diet based on the United States Department of Agriculture MyPlate nutrition recommendations and aerobic and resistance training four days per week for eight weeks. |
|
| Paleolithic | Active Comparator | To consume a weight maintenance diet based on alternative (Paleolithic based) nutrition recommendations for eight weeks. |
|
| Paleolithic + Exercise | Active Comparator | To consume a weight maintenance diet based on alternative (Paleolithic based) nutrition recommendations and aerobic and resistance training four days per week for eight weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MyPlate | Behavioral | To consume a weight maintenance diet based on the United States Department of Agriculture MyPlate nutrition recommendations for eight weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in aerobic conditioning | Peak oxygen consumption | Baseline and 8 weeks |
| Change in anaerobic power | Wingate anaerobic threshold | Baseline and 8 weeks |
| Change in strength | Chest press and leg press estimated one repetition maximum | Baseline and 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in resting energy expenditure | 24 hour kcal and respiratory quotient | Baseline and 8 weeks |
| Change in urine | Osmolality | Baseline and 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in free living activity | Armband activity monitor worn on the upper left arm (METs) | Baseline and 8 weeks |
| Change in blood pressure | Systolic and diastolic blood pressure |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clemson University | Clemson | South Carolina | 29631 | United States |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D066046 | Diet, Paleolithic |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| MyPlate + Exercise | Behavioral | To consume a weight maintenance diet based on the United States Department of Agriculture MyPlate nutrition recommendations and aerobic and resistance training four days per week for eight weeks. |
|
| Paleolithic | Behavioral | To consume a weight maintenance diet based on alternative (Paleolithic based) nutrition recommendations for eight weeks. |
|
| Paleolithic + Exercise | Behavioral | To consume a weight maintenance diet based on alternative (Paleolithic based) nutrition recommendations and aerobic and resistance training four days per week for eight weeks. |
|
| Change in insulin (plasma) | Radioimmunoprecipitation assay | Baseline and 8 weeks |
| Change in glucagon (plasma) | Radioimmunoprecipitation assay | Baseline and 8 weeks |
| Change in ghrelin (plasma) | Total and active ghrelin; Radioimmunoprecipitation assay | Baseline and 8 weeks |
| Change in peptide YY 3-36 (plasma) | Radioimmunoprecipitation assay | Baseline and 8 weeks |
| Change in adiponectin (plasma) | Radioimmunoprecipitation assay | Baseline and 8 weeks |
| Change in leptin (plasma) | Radioimmunoprecipitation assay | Baseline and 8 weeks |
| Change in tumor necrosis factor alpha (plasma) | ELISA | Baseline and 8 weeks |
| Change in interleukin 6 (plasma) | ELISA | Baseline and 8 weeks |
| Change in undercarboxylated osteocalcin (plasma) | enzymeimmunoassay | Baseline and 8 weeks |
| Change in total cholesterol (plasma) | Colorimetric enzyme assay | Baseline and 8 weeks |
| Change in HDL cholesterol (plasma) | Colorimetric enzyme assay | Baseline and 8 weeks |
| Change in non-HDL cholesterol (plasma) | Calculated from triacylglycerol, total cholesterol and HDL cholesterol | Baseline and 8 weeks |
| Change in triacylglycerol (plasma) | Colorimetric enzyme assay | Baseline and 8 weeks |
| Change in non-esterified fatty acids (plasma) | Colorimetric enzyme assay | Baseline and weeks |
| Change in glucose (plasma) | Colorimetric enzyme assay | Baseline and 8 weeks |
| Change in ketones (plasma) | Colorimetric enzyme assay | Baseline and 8 weeks |
| Change in fat mass | Dual energy x-ray absorptiometry | Baseline and 8 weeks |
| Change in fat free mass | Dual energy x-ray absorptiometry | Baseline and 8 weeks |
| Change in bone mass | Dual energy x-ray absorptiometry | Baseline and 8 weeks |
| Baseline and 8 weeks |
| Change in resting heart rate | Beats per minute | Baseline and 8 weeks |
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |