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| Name | Class |
|---|---|
| Norwegian School of Sport Sciences | OTHER |
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The study evaluates the effect of exercise and/or diet during on body weight, body composition and health related blood parameters. Participants are overweight sedentary females, allocated to four different groups: Normal diet, Low-carb-high-fat diet, Normal diet + exercise, Low-carb-high-fat diet + exercise.
Diet and exercise can both be efficient tools to reduce bodyweight, get healthier body composition and improve many different health related blood parameters such as cholesterol and glucose tolerance.
Exercise has superior effect on skeletal muscle in the context of glucose tolerance, but adherence to exercise program can be a huge challenge for overweight individuals. While exercise has profound effect on metabolic health, diet has been superior when it comes to weight reduction. Previous studies have shown that 5-7% weight loss can improve glucose tolerance, measured as reduced fasting glucose and reduced 2-hour post prandial glucose.
We wish to see if the combination exercise and diet is superior to diet only when it comes to over all health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal diet | Experimental | The group ingests normal diet, recommended by the health authorities |
|
| LCHF diet | Experimental | The group ingests LCHF diet, a modified Atkins diet with 70 energy percentage fat |
|
| Normal diet + exercise | Experimental | The group ingests normal diet, recommended by the health authorities in addition to exercise program 3x week. |
|
| LCHF diet + exercise | Experimental | The group ingests LCHF diet, a modified Atkins diet with 70 energy percentage fat, in addition to exercise program 3x week. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Other | Exercise program - indoor bicycle interval exercise, duration 60 min 3x week |
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| Measure | Description | Time Frame |
|---|---|---|
| Area under curve (AUC) glucose | AUC glucose measured during an OGTT | Change from baseline AUC glucose at 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Lipid profile | Measurements of total cholesterol, LDL, HDL, TG | Change from Baseline lipids at 10 weeks |
| Body composition | Measurement of lean body mass, fat free mass, fat mass, visceral fat, bone mass |
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Inclusion Criteria:
Exclusion Criteria:
Premenopausal
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| Name | Affiliation | Role |
|---|---|---|
| Jørgen Jensen, Professor | Norwegian School of Sport Sciences, Section of Physical Performance | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Norwegian School of Sports Sciences | Oslo | 0863 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36760521 | Derived | Valsdottir TD, Ovrebo B, Kornfeldt TM, Litleskare S, Johansen EI, Henriksen C, Jensen J. Effect of aerobic exercise and low-carbohydrate high-fat diet on glucose tolerance and android/gynoid fat in overweight/obese women: A randomized controlled trial. Front Physiol. 2023 Jan 24;14:1056296. doi: 10.3389/fphys.2023.1056296. eCollection 2023. |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D007333 | Insulin Resistance |
| D001835 | Body Weight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Diet and exercise, or diet only
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| Normal Diet | Other | Normal diet recommended by the health authorities |
|
| LCHF Diet | Other | LCHF Diet, a modified Atkins diet with high percentage of fat and very low percentage of karbohydrates |
|
| Change from baseline values at 10 weeks |
| Cardiorespiratory fitness | Measurement of peak oxygen uptake | Change from baseline values at 10 weeks |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |