Hypothalamo-pituitary Adrenal Axis Activity and Neuropsychological Consequences in Type 1 Diabetes in Childhood

Hypothalamo-pituitary Adrenal Axis Activity: Relation With Neuropsychological Consequences in Type 1 Diabetes in Childhood. The CORTICODIAB Study

The general objective is to precise the role of HPA axis activity in neuropsychological consequences of type 1 diabetes. The investigators hypothesize that hyperactivity of HPA axis is associated with higher scores of depression and changes in hippocampal volume and mean diffusion.

• Background: Type 1 diabetes could be associated with hyperactivity of hypothalamo-pituitary adrenal (HPA) axis. Type 1 diabetes is associated with higher frequency neuropsychological consequences as mood disorders and structural changes in brain, particularly in hippocampus.
• Purpose: To describe the association between HPA axis activity and anxiety and depression scores in 6-12 year's old diabetes children.
• Abstract: The general objective is to precise the role of HPA axis activity in neuropsychological consequences of type 1 diabetes. The investigators hypothesize that hyperactivity of HPA axis is associated with higher scores of depression and changes in hippocampal volume and mean diffusion.

Inclusion Criteria:

• Diabetic group:

  • diabetes for 1 year
  • 6-12 year's old
  • included in ISIS-DIAB protocol.

• Control group:

  • brother or sister of a diabetic children
  • 6-12 year's old.

Exclusion Criteria:

• Per os or inhaled corticoid in the previous month of inclusion.
• Acute infectious disease in the previous week of inclusion.
• Other chronic disease than diabetes type1.
• Psychiatric disorders or psychiatric treatment.