A Phase III, Open-Label, Randomized Study of Atezolizumab (MPDL3280A, Anti-PD-L1 Antibody) in Combination With Carboplatin+Paclitaxel With or Without Bevacizumab Compared With Carboplatin + Paclitaxel + Bevacizumab in Chemotherapy-Naïve Patients With Stage IV Non-Squamous Non-Small Cell Lung Cancer
A Phase III, Open-Label, Randomized Study of Atezolizumab (MPDL3280A, Anti-PD-L1 Antibody) in Combination With Carboplatin+Paclitaxel With or Without Bevacizumab Compared With Carboplatin + Paclitaxel + Bevacizumab in Chemotherapy-Naïve Patients With Stage IV Non-Squamous Non-Small Cell Lung Cancer
This randomized, open-label study evaluated the safety and efficacy of atezolizumab (an engineered anti-programmed death-ligand 1 [PD-L1] antibody) in combination with carboplatin+paclitaxel with or without bevacizumab compared with treatment with carboplatin+paclitaxel+bevacizumab in chemotherapy-naïve participants with Stage IV non-squamous NSCLC. Participants were randomized in a 1:1:1 ratio to Arm A (Atezolizumab+Carboplatin+Paclitaxel), Arm B (Atezolizumab+Carboplatin+Paclitaxel+Bevacizumab), or Arm C (Carboplatin+Paclitaxel+Bevacizumab).
Inclusion Criteria:
Exclusion Criteria:
Cancer-Specific Exclusions:
General Medical Exclusions:
Exclusion Criteria Related to Medications:
Prahan, Victoria 3181, Australia
Caxias do Sul, Rio Grande do Sul 95070-560, Brazil
Ribeirão Preto, São Paulo 14015-130, Brazil
Bordeaux, 33076, France
Saint-Denis, 97405, France
Dresden, 01307, Germany
Sassari, Sardinia 07100, Italy
Ehime, 791-0280, Japan
Moscovskaya Oblast, Moscow Oblast 143423, Russia
L'Hospitalet de Llobregat, Barcelona 08908, Spain
Liuying Township, 736, Taiwan
Putzu, 613, Taiwan
Xitun Dist., 40705, Taiwan
Dnipropetrovsk, Katerynoslav Governorate 49102, Ukraine
Zaporizhzhya, Katerynoslav Governorate 69040, Ukraine
Kharkiv, Kharkiv Governorate 61070, Ukraine
Uzhhorod, Kherson Governorate 88014, Ukraine
Ivano-Frankivsk, KIEV Governorate 76018, Ukraine
Vinnytsia, KIEV Governorate 21029, Ukraine
Kryvyi Rih, 50048, Ukraine
Poltava, 36011, Ukraine